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Medical Journal of Islamic Republic of Iran، جلد ۴، شماره ۴، صفحات ۲۸۷-۲۹۱
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عنوان انگلیسی CORRELATION BETWEEN ELECTROCARDIOGRAPHIC AND HISTOPATHOLOGICAL CHANGES IN ISOPRENALINE-INDUCED MYOCARDIAL INJURY
چکیده انگلیسی مقاله Myocardial injury was induced in 25 dogs by infusing isoprenaline, 2-4 microgram per kg per minute for the duration of six hours. 10 dogs served as controls which received only physiological saline. Animals receiving isoprenaline 2 microgram per kg per minute were labelled as experimental group A and other receiving microgram per kg per minute as experimental group B. Histopathological observations in experimental groups A & B showed subendocardial haemorrhage in the papillary muscles and apex of left ventricle as early as two-three hours of infusion. Focal lesions characterized by congestion, dilatation and extravasation of blood was observed near necrotic myocardium. Group A animals showed only severe tachycardia while in group B myocardial infarction in 80% and only ischaemic changes in 20% of animals were observed. Out of animals in group B, 37.5% developed myocardial infarction after two hours of infusion while remaining 62.5% developed changes after four hours. Histopathological changes were very well correlated with ECG findings observed in the present study.
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نویسندگان مقاله keshav anand | keshav anand
form the amp;apos; dept. of physiology, medical school, kerman university of medical sciences, kerman

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

saroj pande | saroj pande
dept. of physiology, maulana azad medical college, new delhi, india


rk گوپتا | rk gupta
dept. of pathology, medical school, kermanuniversity of medical sciences, kerman, islamic republic of iran.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-737&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Physiology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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