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Medical Journal of Islamic Republic of Iran، جلد ۲، شماره ۲، صفحات ۱۱۹-۱۲۲
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عنوان انگلیسی MEDICAL TREATMENT OF TOXIC GOITER IN AN AREA OF IODINE DEFICIENCY
چکیده انگلیسی مقاله The response to methimazole [1-methyl-2-mercapto-imidazole (MMI)] therapy, 10 mg twice daily in 15 patients and propylthiouracil (P TU) therapy, 100mg twice daily in 10 patients with diffuse toxic goiter was evaluated in an area of iodine deficiency (Tehran). The mean free T4 index (FT4I) decreased from 22.7± 6.8 (± SD) to 10.8± 2.8 In MMI-treated, and from 25.1± 6.8 to 13.2± 2.1 in PTU-treated patients, two weeks after treatment. The FT4I further decreased to 6.8± 4.3 and 8.5± 2.1 after four weeks of MMI and PTU administration, respectively. The mean free T3 index (FT3I) was 415± 90, 162± 44 and 117± 46 in MMI treated and 430± 80, 210± 45 and 140± 53 in PTU treated patients before and two and four weeks after treatment, respectively. The mean FT4I and FT 31 had decreased more in the MMI treated groups as compared to the PTU treated patients, two weeks after treatment. In patients treated with MMI or PTU, 11 of 25 (44 %) had subnormal FT 41 after four weeks of treatment, of whom one had increased serum TSH. These results indicate that treatment with less than the recommended doses of thionamide compounds causes a rapid decline of thyroid hormone indices in patients residing iI). Tehran. The dosage of thionamide compounds as well as the duration of therapy with the initial doses necessary to induce euthyroidism, should be evaluated in various parts of the world.
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نویسندگان مقاله فریدون عزیزی | fereydoon azizi
from the department of medicine, taleghani medical center, shahid beheshti university of medical sciences, tehran, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-508&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Internal Medicine
نوع مقاله منتشر شده Original Research
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