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International Journal of Radiation Research، جلد ۱۴، شماره ۲، صفحات ۱۱۳-۱۱۸
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عنوان انگلیسی Radio-protective effect of hydrogen rich water combined with amifostine in mice
چکیده انگلیسی مقاله Background: Hydrogen has been demonstrated can selectively reduce the hydroxyl, which is the main cause of ionizing radiation-induced damage. Amifostine (AM) is the only radioprotective drug approved by the U.S. Food and Drug Administration for use in radiotherapy. The purpose of the present study was to investigate the combined radio-protective effect of hydrogen rich water (HRW) and AM. Materials and Methods: Male ICR mice were treated intragastrically with HRW or/and intraperitoneally with AM 30 minutes prior to 9.0 Gy whole body irradiation from a 60Co source (dose rate 0.96Gy/min). Then the survival rate for 30 days, the hematological parameters, the Clinical chemistry parameters and the bone marrow nucleated cells were examined. Results: We found that the mice treated with HRW and AM before irradiation could increase the 30-day survival rate and improve the body weight better than the HRW or AM treatment alone group and irradiation alone group. Hematological test and Clinical chemistry assays also showed the same results that HRW combined AM could better improve the recovery of hemopoietic system and alleviate the detrimental effects of radiation. Conclusion: The results indicate that the combined application of HRW and AM may be a better method for radiation therapy.
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نویسندگان مقاله x qin | x. qin
department of occupational health, school of public health, shanxi medical university, taiyuan, 03001, china


j yin | j. yin
department of radiation medicine and environment medicine, china institute for radiation protection, taiyuan, 030006, china


| j. wen
department of radiation medicine and environment medicine, china institute for radiation protection, taiyuan, 030006, china


| j. wen
department of radiation medicine and environment medicine, china institute for radiation protection, taiyuan, 030006, china


| j. wen
department of radiation medicine and environment medicine, china institute for radiation protection, taiyuan, 030006, china


q niu | q. niu
department of occupational health, school of public health, shanxi medical university, taiyuan, 03001, china
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-606&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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