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International Journal of Radiation Research، جلد ۱۳، شماره ۴، صفحات ۲۹۷-۳۰۳
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عنوان انگلیسی Neuroprotective effects of propolis and caffeic acid phenethyl ester (CAPE) on the radiation-injured brain tissue (Neuroprotective effects of propolis and CAPE)
چکیده انگلیسی مقاله Background: Our purpose was to investigate propolis and its component caffeic acid phenethyl ester (CAPE) for their antioxidant effects on the brain tissue of rats exposed to ionizing radiation (IR). Materials and Methods: Fifty-four male albino Sprague-Dawley rats, divided into six groups, were designed as normal control group, cranial irradiation of 5 Gray alone, irradiation plus CAPE, irradiation plus propolis, control groups of propolis and CAPE. Oxidative/antioxidative status indicators, lipid peroxidation and antioxidant enzymes, were determined by biochemical methods in homogenized brain tissue of rats. Results: Malondialdehyde level, the lipid peroxidation index, in the irradiation alone group was found to be significantly increased compared to all of the other groups (p< 0.001). Enzyme activities of superoxide dismutase (SOD) were 504.93, 720.70 and 659.98 for irradiation alone group, irradiation plus CAPE group and irradiation plus propolis group, respectively. Enzyme activity of SOD in the irradiation alone group was found to be significantly decreased compared to the groups received propolis or CAPE (p< 0.003). Enzyme activity of glutathione peroxidase was not found statistically different among all of the groups. Conclusion: Propolis and CAPE were found to be beneficial agents in protecting brain tissue against IR-induced oxidative damage.
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نویسندگان مقاله حمزه alkis | h e alkis
department of radiation oncology, gaziantep university, medical school, gaziantep, turkey


عبدالرحمان kuzhan | abdurahman kuzhan
department of radiation oncology, gaziantep university, medical school, gaziantep, turkey


a dirier | a. dirier
department of radiation oncology, gaziantep university, medical school, gaziantep, turkey


m tarakcioglu | m. tarakcioglu
department of biochemistry and clinical biochemistry, gaziantep university, medical school, gaziantep, turkey


e demir | e. demir
department of biochemistry and clinical biochemistry, gaziantep university, medical school, gaziantep, turkey


e saricicek | e. saricicek
department of biochemistry, dr. ersin arslan state hospital, gaziantep, turkey


t demir | t. demir
department of physiology, gaziantep university, medical school, gaziantep, turkey


a ahlatci | a. ahlatci
department of radiation oncology, gaziantep university, medical school, gaziantep, turkey


a demirci | a. demirci
department of radiation oncology, gaziantep university, medical school, gaziantep, turkey


k cinar | k. cinar
department of neurosurgery, sehitkamil state hospital, gaziantep, turkey
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-576&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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