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International Journal of Radiation Research، جلد ۱۳، شماره ۳، صفحات ۲۰۵-۲۱۲
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عنوان انگلیسی Concurrent chemoradiotherapy in locally advanced non-small cell lung cancer: a retrospective analysis of the correlation between radiotherapy-related factors and tumor response
چکیده انگلیسی مقاله Background: To determine which radiotherapy parameters are associated with the tumor response of locally advanced non-small cell lung cancer (NSCLC) patients undergoing concurrent chemoradiotherapy. Materials and Methods: Thirty one patients with IIIA/IIIB NSCLC underwent chemoradiotherapy with a median dose of 63 Gy. On our actual treatments, we made radiotherapy planning to cover the planning target volume (PTV) with 95% of the prescribed dose, and checked the second CT simulation when a cumulative dose was about 36 Gy. For this study, each PTV of primary tumor was re-defined with even margins from the gross target volume (GTV), and the actual plan overlaid the re-defined PTV. The correlations between the tumor response rate during chemoradiotherapy and after chemoradiotherapy, and the dose distribution parameters (D95, V95, mean tumor dose and homogeneity index), total dose and GTV, were evaluated. Results: Median overall survival was 15.5 months and the two-year survival 42.3%. At first recurrence, radiation-field recurrence, distant metastases and simultaneous recurrence were developed in 35.5%, 41.9% and 9.7% of the cases, respectively. The dose distribution parameters were generally favorable and were not related with tumor response rate. The tumor response rate after chemoradiotherapy was correlated with the residual GTV at second simulation (&gamma=-0.627, p< 0.001) and the tumor response rate during chemoradiotherapy (&gamma=0.541, p=0.003). Conclusion: Minimal correlation was found between the dose distribution parameters that were over the minimal dose requirement and tumor response in NSCLC with concurrent chemoradiotherapy. The small residual volume during chemoradiotherapy could indicate good tumor response after chemoradiotherapy.
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نویسندگان مقاله y j سونگ گو | y j park
department of radiation oncology, ansan hospital, korea university medical center, ansan, republic of korea


w s yoon | w s yoon
department of radiation oncology, ansan hospital, korea university medical center, ansan, republic of korea


جبار lee | j a lee
department of radiation oncology, ansan hospital, korea university medical center, ansan, republic of korea


نرجس خاتون lee | n k lee
department of radiation oncology, ansan hospital, korea university medical center, ansan, republic of korea


s lee | s. lee
department of radiation oncology, ansan hospital, korea university medical center, ansan, republic of korea


d s یانگ | d s yang
department of radiation oncology, ansan hospital, korea university medical center, ansan, republic of korea


c y کیم | c y kim
department of radiation oncology, ansan hospital, korea university medical center, ansan, republic of korea


ژاک اچ کیم | j h kim
department of internal medicine, ansan hospital, korea university medical center, ansan, republic of korea
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-563&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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