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Molecular Biology Research Communications، جلد ۸، شماره ۳، صفحات ۱۱۹-۱۲۸
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عنوان انگلیسی Novel Isatin-based activator of p53 transcriptional functions in tumor cells
چکیده انگلیسی مقاله Bioinorganic medicinal chemistry remains a hot field for research aimed at developing novel anti-cancer treatments. Discovery of metal complexes as potent antitumor chemotherapeutics such as cisplatin led to a significant shift of focus toward organometallic/ bioinorganic compounds containing transition metals and their chelates as novel scaffolds for drug discovery. In that way, transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. Here, we report novel data on p53 activating Isatin-based Cu(II) complex exhibiting cytotoxic properties towards HCT116 and MCF7 tumor cell lines, as confirmed by cell viability assay and flow cytometry analysis of apoptosis. Furthermore, putative p53-mediated mechanism of action of this compound is supported by quantitative analysis of TP53, MDM2 and PUMA genes expression, as well as luciferase-based p53 pathway activation assay. Multiplex immunoassay analysis of inflammatory markers revealed potential modulation of several cytokines and chemokines.
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نویسندگان مقاله Regina Mirgayazova |
Kazan Federal University, Kazan, Russian Federation

Raniya Khadiullina |
Kazan Federal University, Kazan, Russian Federation

Rimma Mingaleeva |
Kazan Federal University, Kazan, Russian Federation

Vitaly Chasov |
Kazan Federal University, Kazan, Russian Federation

Marina Gomzikova |
Kazan Federal University, Kazan, Russian Federation

Ekaterina Garanina |
Kazan Federal University, Kazan, Russian Federation

Albert Rizvanov |
Kazan Federal University, Kazan, Russian Federation

Emil Bulatov |
Kazan Federal University, Kazan, Russian Federation

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_5321_907e023bb67ee085f2d6660fbf09c56a.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/526/article-526-1930696.pdf
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