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Journal of Research in Medical Sciences، جلد ۲۳، شماره ۱، صفحات ۲۰۱۸-۲۳
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عنوان انگلیسی The effect of testosterone gel on fertility outcomes in women with a poor response in in vitro fertilization cycles: A pilot randomized clinical trial
چکیده انگلیسی مقاله Background: In this study, the e?ect of testosterone gel administration during ovulation induction on the fertility rate was examined in women with a poor ovarian response in in vitro fertilization (IVF) cycles. Materials and Methods: Te current study is a single?blinded, randomized clinical trial. Patients who met inclusion (Bologna) criteria were placed in the antagonist cycle group. Te patients were randomly divided into two groups each included 25 participants treated with a placebo (lubricant gel, the controls) and testosterone gel (intervention). Fertility outcomes were compared between two study groups. Results: Te mean ± standard deviation (SD) age of intervention (41.04 ± 3.77) versus control group (39.69 ± 3.29) was not statistically di?erent. Te two studied groups were not statistically di?erent in terms of follicle?stimulating hormone; antral follicle count, IVF, anti?Mullerian hormone, and the duration of infertility. Te mean ± SD of oocyte 2.48 ± 1.64 versus 1.17 ± 1.27 and embryo 1.60 ± 1.58 versus 0.39 ± 0.58 in intervention group was signifcantly higher than control group ( P < 0.01). Te rate of pregnancy 16% versus 0% and embryo of quality A–B was signifcantly higher in intervention group than control (60% versus 17.4%, P < 0.05). Conclusion: Te results of the current study showed that the testosterone gel has a signifcant impact on the fertility rate in women with a poor response in the IVF cycles. Further, randomized clinical trials with larger sample sized are recommended.
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نویسندگان مقاله | Nasrin Saharkhiz


| Shahrzad Zademodares


| Saghar Salehpour


| Sedighe Hosseini


| Leyla Nazari


| Hatav Ghasemi Tehrani


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10754
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-1956574.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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