این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Radiation Research، جلد ۲، شماره ۳، صفحات ۱۰۷-۱۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Preparation of [64Cu] Pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a PET and/or therapeutic radiopharmaceutical
چکیده انگلیسی مقاله Background: Copper-64 (T1/2=12.7 h) is an important radionuclide used both in PET imaging and therapy. [64Cu]-pyruvaldehyde-bis (N4-methylthiosemicarbazone) ([64Cu]-PTSM) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). The wide range of 64Cu applications arouse great interest for its production. Materials and Methods: Cu-64 was produced via the 68Zn (p, α n) 64Cu nuclear reaction and isolated from the irradiated target by a two-step chemical method. [64Cu]-PTSM was prepared using in-house made PTSM ligand and [64Cu] cuprous acetate. The complex formation parameter s (time, temperature, concentration and elution methods) were determined carefully. Results: Copper-64 was prepared in chloride form (≈200 mCi, >95% chemical yield at 180 μA for 1.1 h irradiation, radionuclidic purity >96%, copper-67 as impurity). The solution of 64Cu-PTSM was prepared in >80% radiochemical yield and more than 98% radiochemical purity. Quality controls and stability tests were performed for the final solution. Conclusion: [64Cu]-PTSM was prepared at the radiopharmaceutical scales with high quality and potential to be used in therapeutic/imaging centers. Iran . J. Radiat. Res., 2004 2 (3): 107-115
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله a r جلیلیان | a r jalilian
cyclotron amp;amp; nuclear medicine department, nuclear research center for agriculture and medicine, karaj, iran


p rowshanfarzad | p rowshanfarzad


j معافیان | j moafian


m کمالی دهقان | m kamali dehghan


m میرزایی | m mirzaii


نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-66&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات