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Iranian Journal of Blood and Cancer، جلد ۱۱، شماره ۳، صفحات ۹۶-۱۰۰
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عنوان انگلیسی TPMT and ITPA Gene Polymorphism and Their Adverse Events during Chemotherapy of Acute Lymphoblastic Leukemia among Bangladeshi Children
چکیده انگلیسی مقاله Background: The pharmacogenetic-oriented approach reduces the toxicity and increases the safety of chemotherapeutic agents. 6-mercaptopurin (6-MP) metabolizing enzymes such as thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) contribute to variable responses and adverse effects among leukemia patients treated with 6-MP. The aim of our study was to identify the prevalence of TPMT and ITPA gene polymorphisms among Bangladeshi children with acute lymphoblastic leukemia (ALL) and their association with the adverse effects of 6-MP during the treatment. Methods: We recruited 75 patients with ALL and 75 volunteers with minor illnesses as the control group. Genotyping for TPMT (TPMT*3C, *3B, *2) and ITPA (ITPAc.94C>.A) was performed. The relationship between genotypes and adverse effects of 6-MP was investigated. Results: The frequency of TPMT*3B, TPMT*3C and ITPA polymorphisms among volunteers was 0.006, 0.020, and 0.093, respectively, whereas TPMT*3C and ITPA polymorphisms among ALL patients was 0.010 and 0.153, respectively. ALL patients with the ITPA variant developed fever (OR=6.9, 95% CI=1.99-23.91), neutropenia (OR=7.68, 95% CI=2.21-26.61), hyperbilirubinemia (OR=4.73, 95% CI=1.39-16.07) and raised serum ALT (OR=4.73, 95% CI=1.52-14.68) which were significant in comparison with those without polymorphism. Conclusion: The frequency of ITPAc.94C>A among Bangladeshi children was high. Adverse effects of chemotherapy in patients with ALL suggests the importance of ITPA genotyping in ALL patients prior to starting chemotherapy.
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نویسندگان مقاله | Sanjana Zaman
North South University


| Hiroko Fukushima
University of Tsukuba


| Ryoko Suzuki
Department of Child Health, Graduate School of Comprehensive Human Sciences Majors of Medical Sciences, University of Tsukuba


| Shoji Yoshimatsu
Research Institute of Tuberculosis, Tokyo


| Mohammad Delwer Hossain Hawlader
North South University


| Takashi Fukushima
University of Tsukuba
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-440-1&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/98/article-98-1972668.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pediatric Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
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