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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۵، صفحات ۴۴۸-۴۵۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents
چکیده انگلیسی مقاله The low solubility of the plant-extracted agent like D-limonene in cancer therapy is a critical problem. In this study, we prepared D-limonene-loaded niosomes (D-limonene/Nio) for cancer therapy through in vitro cytotoxicity assay of HepG2, MCF-7, and A549 cell lines. The niosomal formulation was prepared by film hydration technique with Span ® 40: Tween ® 40: cholesterol (35:35:30 molar ratio) and characterized for vesicle distribution size, morphology, entrapment efficiency (EE%), and in vitro release behaviour. The obtained niosomes showed a nanometric size and spherical morphology with EE% about 87 ± 1.8%. Remarkably prolonged release of D-limonene from niosomes compared to free D-limonene observed. The loaded formulation showed significantly enhanced cytotoxic activity with all three cancer cell lines (HepG2, Macf-7 and A549) at the concentration of 20 µM. These results indicated that niosome loaded with phytochemicals can be a promising nano-carrier for cancer therapy applications.
کلیدواژه‌های انگلیسی مقاله Cancer therapy,D-limonene,Niosome,Solubility.
نویسندگان مقاله | Mohammad Reza Hajizadeh
1Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran. 2Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Haniyeh Maleki
3Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, I.R. Iran.


| Mahmood Barani
4Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Ttorbat Heydariyeh, I.R. Iran.


| Mohammad Ali Fahmidehkar
5Department of Clinical Biochemistry, Afzalipoor Faculty of Medicine, Kerman University of Medical Sciences, Kerman, I.R. Iran.


| Mehdi Mahmoodi
6Department of Biotechnology, Institute of Science, High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, I.R. Iran.


| Masoud Torkzadeh-Mahani


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1935
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1991901.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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