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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۱۱، صفحات ۱۳۳۱-۱۳۳۹
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عنوان انگلیسی Potential therapeutic effect of Moroccan propolis in hyperglycemia, dyslipidemia, and hepatorenal dysfunction in diabetic rats
چکیده انگلیسی مقاله Objective(s): The effect of propolis collected in Morocco on blood glucose, lipid profile, liver enzymes, and kidney function was investigated in control and diabetic rats. Materials and Methods: Antioxidant activity of propolis was evaluated with the use of DPPH, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+), ferric reducing power and total antioxidant activity assay. To study its effect in streptozotocin (STZ)-induced diabetes, the rats were divided into eight groups; four control and four diabetics. The animals received distilled water, glibenclamide, or propolis extract, 50 mg/kg/BW) or 100 mg/kg/b.wt, daily for 15 days. Blood glucose, triglyceride, lactic acid dehydrogenase, liver enzymes, creatinine, blood urea, lipid profile, and body weight were measured on day 15 after commencement of the treatment. Results: Propolis has a strong antioxidant activity and high total flavonoids and polyphenols content. Glibenclamide and propolis have no significant effect on lipid parameters, and renal and hepatic function in non-diabetic rats. However, propolis or glibenclamide caused a significant lowering of blood glucose after a single administration and at day 15 after daily administration in diabetic rats (P
کلیدواژه‌های انگلیسی مقاله Antioxidant, Diabetes, Kidney, Liver, Propolis
نویسندگان مقاله | Nawal El Menyiy
Laboratory Physiology-Pharmacology & Environmental Health, Faculty of science Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez, Morocco


| Noori Al-Waili
New York Medical Care for Nephrology, New York City, NY, USA


| Asmae El Ghouizi
Laboratory Physiology-Pharmacology & Environmental Health, Faculty of science Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez, Morocco


| Soukaina El-Guendouz
Laboratory Physiology-Pharmacology & Environmental Health, Faculty of science Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez, Morocco


| Khelod Salom
New York Medical Care for Nephrology, New York City, NY, USA


| Badiaa Lyoussi
Laboratory Physiology-Pharmacology & Environmental Health, Faculty of science Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez, Morocco
نشانی اینترنتی http://ijbms.mums.ac.ir/article_13937.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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