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Medical Journal of Islamic Republic of Iran، جلد ۲۹، شماره ۱، صفحات ۶۱۵-۶۲۱
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عنوان انگلیسی Prevalence of osteoporosis and vitamin D receptor gene polymor-phisms (FokI) in an Iranian general population based study (Kurdistan) (IMOS)
چکیده انگلیسی مقاله Background: Osteoporosis, or porous bone, is a disease characterized by low bone mass density (BMD) and structural deterioration of bone tissue, leading to bone fragility and increased risk of hip, spine, and wrist fractures. There are numerous risk factors for osteoporosis. While many of these factors are non-genetic in nature, there is a definite genetic component responsible for this condition. The main aim of this study was to evaluate the association between VDR (Vitamin D receptor gene) polymorphisms (Fok1) A>G (rs2228570) and bone mineral density in an Iranian defined population. Methods : The study participants comprised of 1032 Iranians recruited from the city of Sanandaj during IMOS (Iranian Multi Center Osteoporosis Study). Bone mineral density measurement was performed in all the participants with and without osteoporosis. All samples were genotyped for VDR genes (Fok1) polymorphism with polymerase chain reaction, using a predesigned TaqMan allele discrimination assay. Results : There was a significant association between Fok1 polymorphism and osteoporosis in post-menopausal women, 0.138(0.025-0.768). Conclusion : It seems that cohort studies, which are more powerful than case-control studies, can be useful in evaluating the roles of genetic variants as risk or protective factors for osteoporosis.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله زهرا محمدی | zahra mohammadi
osteoporosis research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Osteoporosis Research Center | Endocrinology and Metabolism Clinical Sciences Institute

عباسعلی کشتکار | abbasali keshtkar
osteoporosis research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Osteoporosis Research Center | Endocrinology and Metabolism Clinical Sciences Institute,

فاطمه فیاض بخش | fateme fayyazbakhsh
biomedical engineering department, maziar university, rouyan, iran.


مهدی ابراهیمی | mehdi ebrahimi
osteoporosis research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Osteoporosis Research Center | Endocrinology and Metabolism Clinical Sciences Institute

مهسا m آملی | mahsa m amoli
endocrinology and metabolism research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Endocrinology and Metabolism Research Center |Endocrinology and Metabolism Clinical Sciences Institute

مصطفی قربانی | mostafa ghorbani
alborz university of medical sciences, karaj, iran.


پاتریشیا خشایار | patricia khashayar
osteoporosis research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Osteoporosis Research Center |Endocrinology and Metabolism Clinical Sciences Institute

محبوبه دینی | mahboubeh dini
non-communicable disease department, iran ministry of health and medical education, tehran, iran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

مینا ابراهیمی راد | mina ebrahimi rad
biochemistry department, pasteur institute of iran, tehran, iran.

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

باقر لاریجانی | bagher larijani
endocrinology and metabolism research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Endocrinology and Metabolism Research Center | Endocrinology and Metabolism Clinical Sciences Institute

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-858&slc_lang=en&sid=en
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