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Acta Medica Iranica، جلد ۵۷، شماره ۶، صفحات ۳۶۸-۳۷۳
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عنوان انگلیسی The Effect of Purgative Manna and Clofibrate on Neonatal Unconjugated Hyperbilirubinemia
چکیده انگلیسی مقاله This study was conducted to determine the effect of purgative Manna and clofibrate on unconjugated hyperbilirubinemia of term neonates. In this randomized clinical trial study, sixty neonates suffering from unconjugated hyperbilirubinemia were evaluated. The neonates were divided into three groups using balanced block randomization. Group A (control group-received only phototherapy), group B (intervention group-received purgative Manna and phototherapy) and group C (intervention group-received clofibrate and phototherapy). After the intervention, the amount of serum bilirubin reduction was compared between groups. There was no significant difference among group A, B, and C in terms of serum bilirubin reduction in 24, 48 and 72 hours after starting the intervention (P>0.05). The hospital stays in the control group was significantly longer than the intervention groups (P< 0.05). No side effects were observed related to using purgative Mienna and clofibrate. The present study showed that prescribing of purgative Manna and clofibrate has no effect on reduction of serum bilirubin level in term neonates with unconjugated hyperbilirubinemia. Thus, it seems that the administration of these drugs is not necessary. Further studies in this regard are recommended.
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نویسندگان مقاله | Abolfazl Mahyar
Department of Pediatrics, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.


| Shahrokh Mehrpisheh
Department of Neonatology, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.


| Bahman Khajeh
Department of Neonatology, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.


| Parviz Ayazi
Department of Pediatrics, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.


| Sonia Oveisi
Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.


| Shifteh Mahyar
School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.


| Shiva Esmaeili
Department of Statistics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7685
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-2204121.pdf
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