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Iranian Journal of Parasitology، جلد ۱۵، شماره ۱، صفحات ۷۶-۸۳
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عنوان انگلیسی In Vitro Effects of Pumpkin (Cucurbita moschata) Seed Extracts on Echinococcus granulosus Protoscoleces
چکیده انگلیسی مقاله Background: Echinococcus granulosus parasite causes a zoonotic disease which is important for public and veterinary health. Since pumpkin seeds (Cucurbita sp.) are used as traditional vermifuge in Iran, they may be a potential herbal anthelmintic. Methods: This study was designed in 2016 to evaluate the in vitro scolicidal effect of Cucurbita moschata seeds form northern part of Iran. Hydroalcoholic and petroleum ether extracts were prepared by maceration and soxhlet respectively. Both extracts with four different concentrations (100, 10, 1, 0.1 mg/ml) were incubated against protoscoleces in 5, 15, 30 and 60 min. Results: Maximum mortality was 16% with 1% hydroalcoholic extract in 60 min. The highest mortality with organic extract was 4% with 10% concentration in 60 min (P=0.015). Conclusion: Since highest mortality was 16%, the extract did not reach to LD50 (50% mortality). Therefore, the potency of the total extract is not sufficient as potential scolicidal drug.
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نویسندگان مقاله | Zahra HESARI
Department of Pharmaceutics, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran


| Meysam SHARIFDINI
Department of Medical Parasitology and Mycology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran


| Mohammad Kazem SHARIFI-YAZDI
Zoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran .Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Teh-ran, Iran


| Saeedeh GHAFARI
School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Sara GHASEMI
School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Shahram MAHMOUDI
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mehdi MOHEBALI
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Bahram NIKMANESH
Zoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran .Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Teh-ran, Iran
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/2838
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/69/article-69-2318188.pdf
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