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Journal of Reproduction and Infertility، جلد ۲۱، شماره ۲، صفحات ۱۰۷-۱۱۶
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عنوان انگلیسی Outcomes of Preimplantation Genetic Testing for Single Gene Defects in a Privately Funded Period and Publicly Funded Period: A North-American Single Center Experience
چکیده انگلیسی مقاله Background: The purpose of this study was to assess whether the outcomes from IVF-preimplantation genetic testing (IVF-PGT) cycles for single gene defects (SGD) (PGT-M) differ between a privately funded period (PRP) and publicly funded period (PUP).   Methods: A retrospective cohort study was conducted in a North-American single tertiary center. The PRP (March 1998 to July 2010) comprised 56 PGT-M cycles from 58 IVF cycles in 38 couples, and the PUP (August 2010 to May 2015) comprised 59 PGT-M cycles from 87 IVF cycles in 38 couples. One PGT-M cycle is defined as one biopsy procedure from one or serial IVF cycles. A p-value of 0.05 was considered statistically significant.  Results: The clinical pregnancy rates (CPR) per PGT-M cycle were 30.4% and 52.5% in each period, respectively (p=0.021). The live birth rates (LBR) per PGT-M cycle were 21.5% versus 40.9% in each period, respectively (p=0.037). A sub-analysis within the PUP comparing 39 PGT-M cycles from 39 IVF cycles with 20 PGT-M cycles from 49 IVF cycles yielded CPRs per PGT-M cycle of 64.1% and 30.0% and LBRs per PGT-M cycle of 53.8% and 15.0%, in each group, respectively (p< 0.05 for both). Conclusion: The transition from private to public funding and a single embryo transfer (ET) guideline has little impact on embryological and clinical outcomes of PGT-M cycles, and results in lower rates of multiple pregnancies. However, these two systems may serve different populations. 
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نویسندگان مقاله | Talya Shaulov
MUHC Reproductive Centre, Department of Obstetrics and Gynecology, Montreal, Quebec, Canada


| Li Zhang
MUHC Reproductive Centre, Department of Obstetrics and Gynecology, Montreal, Quebec, Canada


| Jin-Tae Chung
MUHC Reproductive Centre, Department of Obstetrics and Gynecology, Montreal, Quebec, Canada


| Weon-Young Son
MUHC Reproductive Centre, Department of Obstetrics and Gynecology, Montreal, Quebec, Canada


| William Buckett
MUHC Reproductive Centre, Department of Obstetrics and Gynecology, Montreal, Quebec, Canada


| Asangla Ao
McGill University Health Centre Research Institute, Montreal, Quebec, Canada
نشانی اینترنتی http://www.jri.ir/article/60079
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/128/article-128-2328663.pdf
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