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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۴، شماره ۲، صفحات ۹۳-۹۸
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عنوان انگلیسی Angiogenesis and Minimal Residual Disease in Patients with Acute Myeloid Leukemia
چکیده انگلیسی مقاله Background: Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults. Bone marrow angiogenesis is crucial for pathogenesis of leukemia, and increasing bone marrow Mean Vascular Density (MVD) and level of angiogenesis factors are seen in patients with AML. Higher level of bone marrow MVD is associated with poor prognosis of AML according to previous studies. The present study aimed to compare bone marrow MVD in AML patients and controls and evaluate the relation between bone marrow MVD and number of residual blast cells after AML treatment. Materials and Methods: This study is a longitudinal study on AML patients who were admitted to Omid hospital. The bone marrow biopsies of patients with AML and patients with normal diagnosis –as control group- were taken from archives of pathology laboratory. Immunohistochemistry staining was used for all specimens by using thrombomodulin markers for calculating MVD. Flow cytometry findings of AML patients were assessed for percent of minimal residual disease (MRD) after AML treatment in AML patients group.                                                                 Results: In this study, 27 AML patients and 24 healthy individuals with mean age of 40.92±15.13 years were evaluated, of whom 56.86% were male. The mean bone marrow MVD was significantly higher in AML patients than controls. The mean bone marrow MVD was significantly higher in males and there was insignificant reverse correlation between bone marrow MVD and MRD. About 59.3% of AML patients had response to treatment and there was no significant relationship between MVD and response to treatment.                      Conclusion: Bone marrow MVD was higher in AML patients than controls and there was no remarkable relationship between bone marrow MVD and MRD and response to treatment.
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نویسندگان مقاله | Pardis Nematollahi
1) Department of Pathology, Cancer Prevention Research Center, Isfahan University of Medical Science, Isfahan, Iran 2) Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Azar Baradaran
Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran


| Zahra Kasaei Koopaei
Department of Pathology, Isfahan University of Medical Science, Isfahan, Iran


| Hamidreza Sajjadieh
Department of Internal Medicine, Isfahan University of Medical Science, Isfahan, Iran
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1111
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