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Iranian Journal of Parasitology، جلد ۱۵، شماره ۲، صفحات ۲۱۴-۲۲۲
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عنوان انگلیسی Clinico-Hematological Findings of Acute Pediatric Visceral Leishmaniasis Referred to the Northeast of Iran during 2005-2015
چکیده انگلیسی مقاله Background: To characterize the epidemiological, clinical, hematological and biochemical features of 33 cases hospitalized with pediatric visceral leishmaniasis (PVL) in North Khorasan Province of Iran from 2005 to 2015. Methods: The serological, hematological and biochemical tests were employed in 33 children between 8 months to 6 yr with a final diagnosis of acute visceral leishmaniasis (VL). The diagnosis of VL was established by microscopic demonstration of Leishmania spp. amastigotes inactive bone marrow aspiration (BMA). Results: The most common presenting features were anemia (82.5%), fever (75%), and hepatosplenomegaly (45.4%). Various hematological parameters showed that most patients were suffering from moderate to severe microcytic hypochromic anemia (78.8% had RBC count less than 4 million cells/ul, 67.7% Hb less than 8 fl). 66.7% of them were leukopenic (WBC: less than 5× 103 /μL) and 24.2% had decreased platelet counts. Pancytopenia was observed in 18.2% of cases. MCV, MCH, and MCHC levels were below the reference range in 88%, 90% and 85.1% of the patients respectively. Moreover, aspartate transaminase (AST) and alanine transaminase (ALT) levels were increased in 53.33% and 6.66% of the patients respectively. 92.9% of cases were C-reactive protein (CRP) positive. Bone marrow was found hyper-cellular in all of them, and myeloid to erythroid ratio (M/E) was more than 4 in 39.1% of cases. Plasma cells slightly were increased in 60% of patients and megakaryocytes were decreased in thrombocytopenic patients. Conclusion: Bone marrow/splenic aspiration still remains the gold standard test despite its risk and pain for patients.
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نویسندگان مقاله | Shaghik BARANI
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Habibollah TURKI
Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Reza SHAFIEI
Vector-Borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Fatemeh JAFARZADEH
Department of Parasitology, Shahid Beheshti Universtiy of Medical Sciences, Tehran, Iran


| Hoda HOSSEINZADEH MALEKI
Mashhad University of Medical Sciences, Mashhad, Iran


| Saber RAEGHI
Department of Laboratory Sciences, Maragheh University of Medical Sciences, Maragheh, Iran
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/2942
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