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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۴، شماره ۳، صفحات ۱۶۷-۱۷۰
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عنوان انگلیسی Atypical Presentation of Thrombotic Thrombocytopenic Purpura without Hematological Features
چکیده انگلیسی مقاله Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease, usually diagnosed with high index of suspicion. The pathophysiology of TTP is due to severe deficiency of von Willebrand factor cleaving protease, known as ADAMTS 13. Early diagnosis is crucial as without treatment TTP is associated with high mortality rate. Plasma exchange is currently the mainstay of treatment. Nonetheless, the classical pentad of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, neurological dysfunction, kidney dysfunction and fever are seen only in 40 percent of the patients. MAHA and thrombocytopenia are the common presenting features. Presentation with thrombotic complication without hematological features (MAHA and thrombocytopenia) is rare and makes the diagnosis difficult. Herein, we report an unusual presentation of a 53-year-old male, who was initially presented in 2014 with classical features of TTP, however had an atypical presentation of TTP in 2016 with only neurological features without hematological features.  
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نویسندگان مقاله | Balraj Singh
Department of Hematology/Oncology, Saint Joseph University Medical Center, Paterson, New Jersey, United States


| Kok Hoe Chan
Department of Medical Education, Saint Michael's Medical Centre, New York Medical College, New Jersey, United States


| Parminder Kaur
Department of Hematology/Oncology, Saint Joseph University Medical Center, Paterson, New Jersey, United States


| Varun Modi
Orange Regional Medical Centre, New Jersey, USA


| Michael Maroules
Department of Hematology/Oncology, Saint Joseph University Medical Center, Paterson, New Jersey, United States
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1171
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