این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۳۶، شماره ۱، صفحات ۳۱۳-۳۱۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی DNA Banking to Assess Genetic Influences on Schizophrenia
چکیده انگلیسی مقاله Background: Schizophrenia is among the most prevalent psychiatric disorders globally, with a lifetime prevalence rate of 0.3% to 0.7%, characterized by the heterogeneous presence of positive, negative, and cognitive symptoms that affect all aspects of mental activity. We aimed to describe the genetics of schizophrenia to widening our understanding of the inheritance of this illness.    Methods: This quasi-experimental study was conducted in Razi psychiatric hospital in Tehran province, Iran. Recruitment of the study samples was conducted in Tehran, Iran, among patients with schizophrenia and their families. For this purpose, individuals with schizophrenia in 40 families with at least 1 to 2 affected members were identified and selected based on a clinical interview conducted by a psychiatrist and according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. The clinical and paraclinical data, drug and substance usage, and medical treatments were collected through a standardized clinical questionnaire. Besides, the Global Assessment Scale and the Positive and Negative Syndrome Scale were completed for all study participants.    Results: A total of 22 families had a negative family history, and 1 affected member and the rest of the studied families had a positive family history and at least 2 affected members. In addition, genealogical data (family tree) and lymphoblastic cell categories were developed to examine genes, and subsequent research results will be reported in the future.    Conclusion: As the research continues, the approach to sampling must be modified to ensure that the deoxyribonucleic acid bank is as extensively representative as possible of all schizophrenia cases.
کلیدواژه‌های انگلیسی مقاله DNA Banking, Genetics, Schizophrenia, Family History, Iran
نویسندگان مقاله | Gita Sadighi
Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran


| Ali Nazeri Astaneh
Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran


| Hossein Najmabadi
Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran


| Mohammad Reza Khodaei Ardakani
Social Determinants of Health Research Center & Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran


| Saeid Latifi-Navid
Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6381-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Psychiatry
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات