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Medical Journal of Islamic Republic of Iran، جلد ۳۶، شماره ۱، صفحات ۹۷-۱۰۳
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عنوان انگلیسی The Effect of Calorie Restriction and Intermittent Fasting on Impaired Cognitive Function in High-Fat Diet-Induced Obesity Started Post-Weaning in Male Wistar Rat
چکیده انگلیسی مقاله Background: Calorie Restriction (CR) is known as one of the most effective life-extending interventions. Therefore researchers are looking for other interventions or drugs to mimic the mentioned effects. Time-restricted feeding (TRF) has recently gained more attention recently as one of the CR mimetics. Here we evaluate and compare the effects of CR or TRF on cognitive function in young animals fed a high-fat diet (HFD).    Methods: This is an experimental study that three-week-old male Wistar rats (n:52) were subjected to a control diet (n:11) or HFD (n:42). Then the HFD group was divided into 1) 30% calorie restriction (CR), 2) Night Intermittent Fasting (NIF), 3) Day Intermittent Fasting (DIF), and 4) Ad-Libitum (AL) with the standard diet for ten weeks (each of 9). An independent T-test or Mann–Whitney test was used for the first phase and in the second phase of the study, one-way analysis of variance (ANOVA), followed by Tukey post-hoc tests, or Kruskal–Wallis and post-hoc Bonferroni test were used. P-values of < 0.05 were considered significant    Results: Deteriorated mental function was significantly lower in HFD than CON (p= 0.041).  CR was still more efficient than NIF in cognitive function in obese subjects. Post-hoc test indicated that from day 2-4, escape latency was significantly shorter in NIF and CR, which was not seen in other groups (p=0.045).    Conclusion:  While TRF has garnered much attention recently, here we show that CR is still more efficient in learning and memory tasks. Longer fasting times and different fasting periods are recommended to study.
کلیدواژه‌های انگلیسی مقاله Cognitive Function, Calorie Restriction, Intermittent Fasting, Circadian
نویسندگان مقاله | Nazanin Asghari Hanjani
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran


| Negar Zamaninour
Department of Minimally Invasive, Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran


| Somayeh Athari Nik Azam
Cellular and Molecular Nutrition Department, School of Nutritional and Dietetics, Tehran University of Medical Sciences, Tehran, Iran


| Aghafatemeh Hosseini
Department of Statistics and Mathematics, School of Health Management and Information Science, Iran University of Medical Sciences, Tehran, Iran


| Farinaz Nasirinezhad
Physiology Research Center, Department of Physiology, Iran University of Medical Sciences, Teharn.Iran


| MohammadReza Vafa
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3712-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nutrition
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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