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Medical Journal of Islamic Republic of Iran، جلد ۳۶، شماره ۱، صفحات ۶۱-۶۴
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عنوان انگلیسی The Value of Sputum Polymerase Chain Reaction for Detection of Nontuberculous Mycobacteria in Cystic Fibrosis Patients with Negative Nontuberculous Mycobacteria Sputum Culture
چکیده انگلیسی مقاله Background: Cystic Fibrosis (CF) is a life-threatening autosomal recessive disease. The purpose of this study was to evaluate the value of Polymerase Chain Reaction (PCR) in CF patients with Nontuberculous Mycobacteria (NTM) negative sputum culture.    Methods: This is a descriptive cross-sectional study. The population included all children with CF, aged between 5 - 18 years old, with an NTM negative sputum culture. The patient's sputum samples were sent for smear and culture of NTM, RFLP PCR, and PCR sequence.    Results: In total, 57 CF patients with negative NTM sputum culture were enrolled. Nine patients (15.78%) had positive sputum PCR for NTM. Among these strains, Mycobacterium simiae was the most common one with 5 cases (8.77% of total positive cases).    Conclusion: PCR can be used as an alternative diagnostic method for NTM in CF patients with negative NTM sputum culture, always under clinical suspicion of the disease.  
کلیدواژه‌های انگلیسی مقاله Cystic Fibrosis, Nontuberculous Mycobacteria, Polymerase Chain Reaction, Sputum
نویسندگان مقاله | Seyed Hossein Mirlohi
Pediatric Respiratory and Sleep Medicine Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran


| Kambiz Eftekhari
Pediatric Gastroenterology and Hepatology Research Center, Department of Pediatrics, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Rohola Shirzadi
Pediatric Respiratory and Sleep Medicine Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran


| Abolfazl Fateh
Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran


| Morteza Masoumi
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran


| Mohammadreza Modaresi
Pediatric Respiratory and Sleep Medicine Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5620-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pulmonary Disease
نوع مقاله منتشر شده Original Research: Clinical Science
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