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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۱۳۵۵-۱۳۵۹
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عنوان انگلیسی Single-surface Intensive Phototherapy or Double-Surface Intensive Phototherapy in Neonatal Non-Hemolytic Hyperbilirubinemia: A Comparison of Effectiveness and Complications
چکیده انگلیسی مقاله Background: Severe indirect hyperbilirubinemia causes neurotoxicity, leading to potential permanent injuries to the neonatal nervous system. The present study intended to compare the effectiveness and complications of Single-Surface Intensive Phototherapy (SSIP) and Double-Surface Intensive Phototherapy (DSIP) in treating non-hemolytic hyperbilirubinemia in the neonatal ward of the Besat Hospital, Hamadan, Iran.    Methods: In this prospective randomized clinical trial, 150 healthy full-term neonates born between 37-42 weeks gestation with ages < 14 days old and birth weights ≥2500 gr who were affected by non-hemolytic hyperbilirubinemia with total serum bilirubin of 15-20 mg/dL were randomly allocated to two groups. Each group (n=75) underwent either SSIP or DSIP. Demographics, bilirubin level alterations, weight, platelet count, number of defecation per day, and body temperature of the patients were monitored and recorded in a specific questionnaire. Data analysis was performed using SPSS version 26.0 software, with the Chi-square and independent t-test.    Results: The pre-intervention levels of indirect bilirubin were 17.07±1.46 mg/dL in the SSIP group and 17.10±1.54 mg/dL in the DSIP group (P-value = 0.853). After 24 and 48 hours of treatment, the mean indirect bilirubin level of the SSIP group reduced to 13.12±1.71 mg/dL and 9.69±1.68 mg/dL, respectively. In the DSIP group, the levels were 11.85±2.17 mg/dL and 8.43±1.56 mg/dL after 24 and 48 hours of treatment, respectively. The absolute reductions of indirect bilirubin were 7.76±3.28 mg/dL for the SSIP group and 8.96±4.49 mg/dL for the DSIP group (P-value = 0.458). Therefore, the indirect bilirubin levels were significantly different between the groups after 24 and 48 hours of treatment and at the time of discharge (P< 0.05). There were no significant inter-group differences in weight, platelet count, and incidence of skin rash, while the number of defecation and body temperature were higher in the DSIP group (P < 0.05). However, body temperature alterations had no clinical relevance.    Conclusion: Compared to the SSIP, the DSIP showed faster effectiveness and led to a shorter hospital stay, while it did not entail higher levels of complications.
کلیدواژه‌های انگلیسی مقاله Neonates, Non-hemolytic Hyperbilirubinemia, Single-Surface Intensive Phototherapy, Double-Surface Intensive Phototherapy
نویسندگان مقاله | Mohammad Kazem Sabzehei
Pediatric Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Shadi Waisi
Pediatric Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Maryam Shokouhi
Pediatric Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Leili Tapak
Department of Biostatistics, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6913-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neonatal
نوع مقاله منتشر شده Original Research: Clinical Science
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