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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۱۲۰۲-۱۲۰۶
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عنوان انگلیسی An Investigation of the Pathology Report of Bladder Cancer Patients with Radical Cystectomy in Southern Iran, 2013-2018: A Cross-Sectional Study
چکیده انگلیسی مقاله Background: The oncological outcomes of bladder cancer are directly associated with disease pathology and surgical technique. Therefore, we investigated the pathologic factors of radical cystectomy (RC) specimens.    Methods: In this retrospective study, 365 patients who underwent RC between March 2013 to March 2018 in hospitals affiliated to Shiraz University were enrolled. The patients' clinicopathological parameters, such as tumor type, tumor grade, carcinoma in situ, lymph node (LN) involvement, lymphovascular invasion (LVI), perineural invasion (PNI), and age, were recorded from their pathology reports. For comparison of variables, an independent t test was used.  P < 0.05 was regarded as significant. The statistical software SPSS version 22 was used to examine the data.    Results: The participants' mean age was 64.52 ± 11.54 years, and 320 (87.7%) patients were men and 45 (12.3%) were women. The mean dissected LN was 9.69 ± 8.70 nodes and 1.06 ±3.49 of the dissected LNs were involved by tumor. PNI and perivesical invasion were presented in 148 (40.5%) and 96 (26.3%) patients, respectively. Ureteral, urethral, and prostate involvements were seen in 23 (6.3%), 50 (13.7%), and 66 (18.1%) patients. Most patients had pathologic tumor stage 2 (36.4%). Factors such as LVI, PNI, perivesical invasion, and prostate involvement, were strongly correlated with positive LN (P ≤ 0.05).    Conclusion: The examination of the RC specimen is critical for patient care, outcome, and justification of adjuvant therapy.  Factors such as LVI, perineural invasion, perivesical invasion, and prostate involvement were strongly correlated with positive LN.  
کلیدواژه‌های انگلیسی مقاله Bladder Cancer, Radical Cystectomy, Pathology, Lymph Node
نویسندگان مقاله علی اریافر | Ali Ariafar
Department of Urology, School of Medicine, & Urology Oncology Research Center, Shiraz University of Medical Since, Shiraz, Iran


| Shahryar Zeighami
Department of Urology, School of Medicine, Shiraz University of Medical Since, Shiraz, Iran


| Mehdi Salehipour
Department of Urology, School of Medicine, Shiraz University of Medical Since, Shiraz, Iran


| Faisal Ahmed
Urology Research Center, Al-Thora General Hospital, Department of Urology, School of Medicine, Ibb University of Medical Science, Ibb, Yemen


| Sara Saeedi
Department of Urology, School of Medicine, Shiraz University of Medical Since, Shiraz, Iran


| Hossein-Ali Nikbakht
4. Social Determinants of Health Research Center, Health Research Institute, Department of Biostatistics and Epidemiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6066-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Urology and Nephrology
نوع مقاله منتشر شده Original Research
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