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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۱۱۹۰-۱۱۹۳
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عنوان انگلیسی Serum Ferritin, Vitamin D and Pathological Factors in Breast Cancer Patients
چکیده انگلیسی مقاله Background: Breast cancer is one of the most common cancers. Researchers are trying to diagnose the disease through easier and safer methods. Serum markers such as ferritin and vitamin D level would be very helpful. This research could pave the way for more comprehensive studies on how to use this serum factor in breast cancer screening, as well as early detection of the disease in its early stages.    Methods: This study consisted of two groups, the first group comprising patients diagnosed with breast cancer before undergoing any treatment and the second group as control were healthy people. Serum ferritin and vitamin D levels were measured. Pathological information of the patient's tumor, including ER, HER2, KI67, lymphovascular invasion, and disease stage, were collected as well. Data were analyzed by IBM SPSS advanced statistics version 23.0 (SPSS Inc., Chicago, IL). P-value of ≤0.05 was considered significant.    Results: Eighty-eight subjects were enrolled in this study, 29 (33%) breast cancer patients and 59 (67%) healthy women. In breast cancer patients, serum ferritin levels were 106.55±111.25, which were higher than healthy women's serum ferritin 52.71±36.95 (p=0.083). Furthermore, 18 (66.7%) of breast cancer patients and 55 (93.2%) of healthy women had low serum ferritin levels (p=0.001). 3 (11.1%) patients in the cancer group had serum vitamin D deficiency, while all subjects in the control group had serum vitamin D higher than 10 ng/dl (p =0.009).    Conclusion: The results of this study showed a correlation between breast cancer and vitamin D deficiency, and elevated ferritin. Perhaps with further studies, there could be a role in predicting the prognosis and screening of breast cancer for these associations.  
کلیدواژه‌های انگلیسی مقاله Ferritin, Vitamin D, Breast Cancer
نویسندگان مقاله | Pedram Fadavi
Department of Radiation Oncology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Nahid Nafisi
Department of General Surgery, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran


| Ramyar Hariri
Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Kambiz Novin
Department of Radiation Oncology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Mastaneh Sanei
Department of Radiation Oncology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Zahra Razzaghi
4. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Amirmohammad Arefpour
Department of Radiation Oncology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Maryam Garousi
Department of Radiation Oncology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6841-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Oncology
نوع مقاله منتشر شده Original Research
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