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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۱۱۲۰-۱۱۲۵
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عنوان انگلیسی Incidence and Risk Factors of Acute Kidney Injury in Patients Hospitalized with Pneumonia: A Prospective Observational Study
چکیده انگلیسی مقاله Background: Acute kidney injury (AKI) is frequent in hospitalized patients with critical illness and presents in up to one-quarter of patients with non-severe community-acquired pneumonia (CAP), resulting in increased short and long-term mortality. There is a paucity of literature from resource-limited settings regarding the incidence and risk factors for AKI in patients with CAP. In this study, we looked at the incidence and risk factors for AKI in patients hospitalized with CAP in a resource-limited setting    Methods: This prospective observational study conducted over 1 year period included patients ≥ 18 years of age diagnosed with CAP admitted to a tertiary care center. The differences in baseline characteristics between hospitalized CAP patients with and without AKI; and risk factors for AKI and the need for renal replacement therapy (RRT) were analyzed using Chi-square test, t-test, Mann-Whitney U test, and logistic regression with p-value < 0.05 considered statistically significant.    Results: We observed 27.6 % (58/210) of patients had AKI in our study. Patients with AKI had significantly higher baseline comorbidities of chronic kidney disease (p=0.005) and coronary artery disease (p=0.032), and significantly higher uric acid (p=0.002), lower albumin  (p=0.005), lower total protein (p=0.015), higher bilirubin (p=0.001), higher LDH (p=0.041), and higher CURB-65 score (p< 0.001) in addition to elevated creatinine, BUN (p< 0.001) compared to the no-AKI group. The patient group requiring RRT had significantly more males (p=0.019), with significantly higher phosphorus (p=0.038), lower ALT (p=0.022), and expectedly higher creatinine (p< 0.001) and blood urea nitrogen (p=0.016). The adjusted logistic regression analysis revealed that patients with higher CURB-65 scores were at increased odds of undergoing RRT (OR 8.74, 95% CI 5.27 to 12.21, p=0.039).    Conclusion: There is a high incidence of AKI in patients hospitalized for CAP in developing countries. Clinicians should be alert for the prevention and early detection of AKI in CAP patients.
کلیدواژه‌های انگلیسی مقاله Kidney Injury, Pneumonia, Dialysis, CURB-65
نویسندگان مقاله | Muzamil Latief
Department of Nephrology, Government Medical College, Srinagar, Kashmir, India


| Reyaz Ahmed Para
Department of Emergency Medicine, SKIMS, Srinagar, Kashmir, India


| Obeid Shafi
Flushing Hospital Medical Center, New York, USA


| Zhahid Hassan
Department of Medicine, Government Medical College, Baramula, Kashmir, India


| Summyia Farooq
Pathology Division, Government Medical College, Srinagar, Kashmir, India


| Farhat Abbas
Pathology Division, Government Medical College, Srinagar, Kashmir, India
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6258-4&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Internal Medicine
نوع مقاله منتشر شده Original Research
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