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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۸۵۹-۸۶۴
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چکیده فارسی مقاله
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عنوان انگلیسی Comparison of the performance of lipoperoxidation-antioxidant protection system in rats at different periods under immobilization stress effects
چکیده انگلیسی مقاله Background: Under physiological conditions, the activity of the formation of active oxygen is low. The activity of these processes is intensified under stress-induced situations. This study aimed to investigate the role of free-radical oxidation (FRO) in adrenal tissues and immunocompetent organs and cells in mature white rats after 6 hours of immobilization stress.    Methods: The studies were performed on 40 White male rats of the Wistar line with a bodyweight of 200 to 240 g. Two series of experiments were conducted: I series: determination of indices in intact rats (10 rats); II series: determination of indices after a 6-hour immobilization stress action on them. Animals of II series were divided into 3 groups of 10 rats in each: group 1: those undergoing acute immobilization stress, withdrawal from the experiment in 1 hour; group 2: those undergoing acute immobilization stress, withdrawal from the experiment in 25 hours; and group 3: those undergoing acute immobilization stress, withdrawal from the experiment in 49 hours. The obtained data were processed by statistical methods with the help of the "Biostat" and "Excel" software packages.    Results: In groups 1, 2, and 3, the animals were simulated acute immobilization stress by fixing the animals for 6 hours in bright light. The results of the conducted studies indicate changes in lipid peroxidation and antioxidant system (LPO-AOS) in case of immobilization stress-excitation. In developing free-radical pathology at immobilization stress-excitation, the more expressed disturbance of LPO-AOS, and accordingly the intensity of lipoperoxidation in the structural membrane of all investigated organs was high at the initial stage of exposure.    Conclusion: At 49 hours after immobilization, stress less pronounced influence on the lipoperoxidation process was noted. The increase in the intensity of excessive lipoperoxidation testifies to the inhibited manifestation of AOS in the organism.
کلیدواژه‌های انگلیسی مقاله Immobilization Stress, Antioxidation, Free Radicals, Lipid Peroxidation
نویسندگان مقاله | Oralbek Z. Ilderbayev
Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Nur-Sultan, Republic of Kazakhstan


| Gulmira M. Zharmakhanova
Department of Natural Science Disciplines, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Republic of Kazakhstan


| Assem K. Okassova
Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Nur-Sultan, Republic of Kazakhstan


| Akmaral Zh. Nursafina
Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Nur-Sultan, Republic of Kazakhstan


| Gulzhan O. Ilderbayeva
Department of Physiological Disciplines, Semey Medical University, Semey, Republic of Kazakhstan
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6662-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Biological Sciences
نوع مقاله منتشر شده Original Research
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