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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۴۰۹-۴۱۲
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عنوان انگلیسی Evaluation of Helicobacter pylori eradication on the course of childhood nephrotic syndrome and its response to treatment
چکیده انگلیسی مقاله Background: Idiopathic nephrotic syndrome is one of the most common glomerular diseases, which may be secondary to infections or systemic diseases. The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) eradication on childhood nephrotic syndrome.    Methods: In this randomized controlled clinical trial study, 38 children with concomitant idiopathic nephrotic syndrome and H. pylori infection were divided into 2 equal groups; the intervention group received a cotreatment for both diseases and the control group received only nephrotic syndrome treatment. Patients were followed for 6 months. Data were analyzed using SPSS 21 software.  Chi square test, Fisher exact test, and student t test were used. P value < 0.05 was considered statistically significant.    Results: The mean interval time from treatment to the recovery of nephrotic syndrome was 48.36±14.48 days in the intervention group and 51.68± 17.32 days in control groups, which was shorter in the intervention group, but not statistically significant. The recurrence of nephrotic syndrome and the mean number of recurrences in the intervention group were lower than the control group, but were not statistically significant. The frequency of diarrhea in the intervention group was significantly higher than the control group (p=0.003).    Conclusion: In children with concomitant idiopathic nephrotic syndrome and H. pylori infection, the treatment of both diseases may accelerate the recovery and decrease the recurrence of nephrotic syndrome.
کلیدواژه‌های انگلیسی مقاله Nephrotic Syndrome, Helicobacter pylori Infection, Children
نویسندگان مقاله | Hassan Bazmamoun
Department of Pediatric Gastroenterology, Hamadan University of Medical Sciences, Hamadan, Iran


| Danyal Isapour
Department of Pediatric Gastroenterology, Hamadan University of Medical Sciences, Hamadan, Iran


| Zahra Sanaei
Department of Community Medicine, Education Development Office, Hamadan University of Medical Sciences, Hamadan, Iran


| Rahimpour Amiri
Department of Pediatric Nephrology, Hamadan University of Medical Sciences, Hamadan, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6172-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nephrology
نوع مقاله منتشر شده Original Research
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