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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۳۲۲-۳۲۶
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عنوان انگلیسی Single nucleotide polymorphism rs5029937 in TNFAIP3 gene is correlated with risk of rheumatoid arthritis
چکیده انگلیسی مقاله Background: Rheumatoid arthritis (RA) is a progressive and common autoimmune disease with multifactorial etiology. Several pieces of research show that genetic factors play a major role in the incidence of RA. Several genome-wide association studies (GWAS) have identified the tumor necrosis factor alpha inducible protein 3 (TNFAIP3) genes as one of the candidate loci. The TNFAIP3 gene encoding ubiquitin-editing protein A20 witch restricts B cell survival and prevents autoimmunity. Previous studies have indicated that single nucleotide polymorphisms (SNPs) in the TNFAIP3 gene are correlated with several autoimmune disorders. In the present study, we assessed the possible association between SNP rs5029937 (intronic variant) in the TNFAIP3 gene with RA risk in the Iranian population.    Methods: A case-control study using 50 RA patients and 50 control subjects was undertaken to evaluate rs5029937 (G>T) genotypes using real-time PCR high resolution melting method (HRM). The SPSS22 was used for statistical analyses and the significance level was set at P< 0.05.    Results: Logistic regression analysis demonstrates that homozygous TT + heterozygous TG genotypes compared with GG genotype increase the risk of RA (TT+TG vs GG; P= 0.004, OR= 3.46; 95%CI [1.492-8.075]). Also, individuals with allele T were more frequently affected with RA than subjects with G allele (T vs G; P= 0.004, OR= 2.61; 95%CI [1.382-4.919]).    Conclusion: Our findings propose a substantial correlation between rs5029937 (G>T) polymorphism and RA risk in Iranian population.
کلیدواژه‌های انگلیسی مقاله Rheumatoid Arthritis, TNFAIP3 Gene, Single-nucleotide Polymorphism, Autoimmune Disorder, HRM
نویسندگان مقاله | Bahram Pakzad
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran


| Farzaneh Yousefisadr
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran


| Hadi Karimzadeh
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran


| Maryam Mousavi
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran


| Elham Noormohamadi
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran


| Rasoul Salehi
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6060-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Medical Genetics
نوع مقاله منتشر شده Original Research
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