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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۲۶۳-۲۶۹
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عنوان انگلیسی Muscle mass and function are related to respiratory function in chronic obstructive pulmonary disease
چکیده انگلیسی مقاله Background: Chronic obstructive pulmonary disease (COPD), as an airway limitation condition, is accompanied by alteration of muscle mass and function. We aimed to determine the relationship between disease severity and body composition, muscle function, and nutritional status in COPD patients.     Methods: This cross-sectional study was conducted on 129 COPD participants. Muscle strength, body composition, and calf circumference (CC) were measured using a hydraulic hand dynamometer, bioelectrical impedance analysis (BIA), and a tape measure, respectively. Furthermore, fat-free mass index (FFMI), body mass index (BMI) and muscle mass value were calculated by equations. Forced expiratory volume in one second (FEV1) was assessed as well. Nutritional status was also evaluated by subjective global assessment (SGA) questionnaire. SPSS software (version 21 ) was used, chi-square, fisher's exact test, univariate and multivariate linear regression models were used for statistical analysis. P-values less than 0.05 were considered significant.    Results: Based on FEV1 classification, 52.7% of the patients had severe conditions. The reports indicated that the prevalence of low CC was 54.2%, low muscle mass 38.7%, low FFMI 34.8%, low right handgrip strength 61.2% and low left handgrip strength 64.3%. Furthermore, there was an increasing trend based on FEV1 in low CC (p=0.032),  low muscle mass (p=0.005), low FFMI (p=0.002), low right handgrip strength (p=0.004) and low left handgrip strength (p=0.014). The results of univariate analysis showed muscle mass (p=0.036), total protein (p=0.043), FFM (p=0.047), FFMI (p=0.007), SGA (p=0.029), right handgrip strength (p=0.004)  and left hand grip strength (p=0.023) were associated with FEV1. In addition, the results of multivariate analysis demonstrated low values of FFMI (p=0.005)  and right handgrip strength (p=0.042) were the main detrimental factors for FEV1. The results of  multivariate analysis were confirmed by stepwise model.    Conclusion: Low values of muscle mass and function are prevalent among COPD patients. The present study revealed that low FFMI and handgrip strength were closely related to disease severity.
کلیدواژه‌های انگلیسی مقاله Muscle Mass, Lean Body Mass, Nutritional Status, Muscle Strength, Respiratory Disease
نویسندگان مقاله | Afsane Ahmadi
Research Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Zohreh Mazloom
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran


| Mohammad Hassan Eftekhari
2. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran


| Sayed Masoom Masoompour
Noncommunicable Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Mohammad Fararooei
Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Mohammad Hadi Eskandari
Department of Food Sciences and Technology, School of Agriculture, Shiraz University, Shiraz, Iran


| Samrad Mehrabi
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Morteza Zare
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran


| Zahra Sohrabi
8. Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5705-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nutrition
نوع مقاله منتشر شده Original Research: Clinical Science
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