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Medical Journal of Islamic Republic of Iran، جلد ۳۵، شماره ۱، صفحات ۲۲-۳۲
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عنوان انگلیسی Effects of coenzyme Q10 on health-related quality of life, clinical disease activity and blood pressure in patients with mild to moderate ulcerative colitis: a randomized clinical trial
چکیده انگلیسی مقاله Background: Ulcerative colitis (UC) is specified by a chronic mucosal inflammation that has a deleterious impact on the quality of life (QoL). Coenzyme Q10 (CoQ10) appears to influence disease activity by its obvious properties. Therefore, the current research intends to assess the impacts of CoQ10 on QoL, disease activity, and blood pressure in UC patients.    Methods: This clinical trial performed on men and women with UC in 2017 who were attended the gastrointestinal center of Hazrat Rasool Akram Hospital and private clinic. Eighty-eight UC patients were randomly allocated to receive either CoQ10 (200 mg/day) or placebo for 8 weeks. The anthropometric parameters, blood pressure, inflammatory bowel disease questionnaire-32 (IBDQ-32) score, and the Simple Clinical Colitis Activity Index (SCCAI) score were measured pre and post-intervention. P-value < 0.05 was considered to be statistically significant. All statistical analysis was done using SPSS software version 24.    Results: Eighty-six UC patients (44 males) with a mean age of 39.29 (10.19) years completed the trial. The results of between- and within-group analysis revealed that the SCCAI score (p< 0.001 and p< 0.001, respectively), diastolic blood pressure (p=0.025 and p=0.001, respectively), and systolic blood pressure (p=0.001 and p< 0.001, respectively) decremented significantly; while, the mean IBDQ-32 (p< 0.001 and p=0.001, respectively) increased substantially in the CoQ10 group; whereas there was no significant difference in anthropometric indices in both groups.    Conclusion: Findings suggest that CoQ10 can be used as a potential intervention for diminishing the disease severity and blood pressure and may improve QoL and UC patients. IRCT number: IRCT20090822002365N17.
کلیدواژه‌های انگلیسی مقاله Coenzyme Q10, Quality of life, Ulcerative colitis, SCCAI score, IBDQ-32
نویسندگان مقاله | Farnaz Farsi
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran


| Nasser Ebrahimi-Daryani
Division of Gastroenterology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mahmood Barati
Cellular and Molecular Research Center, & Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Science, Tehran, Iran


| Leila Janani
Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute (PHRI), Iran University of Medical sciences, Tehran, Iran


| Mohammad Yahya Karimi
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran


| Abolfazl Akbari
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran


| Pardis Irandoost
Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical sciences, Tehran, Iran


| Naimeh Mesri Alamdari
Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical sciences, Tehran, Iran


| Shahram Agah
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran


| Mohammadreza Vafa
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5875-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Gastroenterology
نوع مقاله منتشر شده Original Research: Clinical Science
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