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Physiology and Pharmacology، جلد ۲۵، شماره ۴، صفحات ۳۳۴-۳۴۰
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عنوان انگلیسی The cardiovascular responses after lipopolysaccharide microinjection into the dorsomedial periaqueductal gray in rats
چکیده انگلیسی مقاله Introduction: The dorsomedial periaqueductal gray (dmPAG) is located around the cerebral aqueduct with various functions such as cardiovascular regulation and is affected by inflammation. Lipopolysaccharide (LPS) is a complex molecule with an inflammatory effect that is known to affect blood pressure. In the present study, the cardiovascular effect of LPS microinjection into the dmPAG was investigated. Methods: Rats were divided into three groups consisting of 1: control; 2: 50 ng LPS and 3:100 ng LPS. Rats were mounted on a stereotaxic device after anesthesia and a continuous recording of cardiovascular parameters was done by a PowerLab device, connected to a cannulated femoral artery and drugs microinjected into dmPAG. The changes (Δ) in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MA) and heart rate (HR) were calculated at different times and compared to the control group. Results: Both doses of LPS when microinjected into the dmPAG brought on a significant hypotensive response in the pressure parameters (MAP, SBP, and DBP) when compared to control. A non-significant increase in HR was also documented in both groups. Conclusion: The results of this experiment indicated that LPS, when microinjected into the dmPAG, induced a hypotensive response in anesthetized rats in both doses in comparison to control.
کلیدواژه‌های انگلیسی مقاله Dorsomedial periaqueductal gray, Lipopolysaccharide, Inflammation, Blood Pressure
نویسندگان مقاله | Reza Mohebbati
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Reza Nejad Shahrokh Abadi
Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Vida Alikhani
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Naser Shafei
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1463-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Experimental research article
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