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Physiology and Pharmacology، جلد ۲۴، شماره ۴، صفحات ۲۵۰-۲۵۶
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عنوان انگلیسی Treadmill exercise improves memory and increases hippocampal BDNF in a rat model of Alzheimer's Disease
چکیده انگلیسی مقاله Introduction: Alzheimer's disease is strongly correlated with learning and memory impairments. As exercise can enhance memory and learning, in this study, we have investigated the effects of treadmill exercise on memory impairment in amyloid β (Aβ)- treated rats focusing on brain-derived neurotrophic factor (BDNF) expression. Methods: Wistar male rats received intracerebroventricular (ICV) injection of Aβ and exercised on a treadmill for one month. Memory function was assessed using Morris water maze (MWM) and avoidance learning tasks. The level of BDNF was examined by the ELISA test. Results: The results of MWM and avoidance learning tasks showed that treadmill exercise could improve Aβ- induced memory impairment significantly. Moreover, BDNF expression increased following exercise in the Aβ- treated rats. Conclusion: The present results suggested that treadmill exercise may improve memory in Alzheimer's disease by increasing BDNF level in the hippocampus.
کلیدواژه‌های انگلیسی مقاله Treadmill exercise, Alzheimer’s disease, Memory, BDNF.
نویسندگان مقاله | Rokhsareh Abshenas
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran


| Tayebe Artimani
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran


| Iraj Amiri
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran


| Siamak Shahidi
Physiology Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Sara Soleimani Asl
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1195-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurophysiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
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