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International Journal of Radiation Research، جلد ۱۹، شماره ۲، صفحات ۴۰۹-۴۱۹
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عنوان انگلیسی Inflammatory response of thymus bystander effects on acute radiation-induced skin injury in rats
چکیده انگلیسی مقاله Background: Radiation not only kills tumor cells, but also damages other sites. The mechanisms of damage caused by the bystander effect of irradiation in animal models are unclear and the time node is single. In this study, we aimed to investigate the inflammatory response of thymus tissue injury in non-irradiated areas at different times after irradiating rat skin. Materials and Methods: Rats were irradiated with an X-ray dose of 38 Gy, and at 15 d after irradiation, when the skin wound was most severe, the pro-inflammatory drug high mobility group box1 (HMGB1) and the anti-inflammatory drug glycyrrhizic acid (GA) were injected intraperitoneally into rats. After irradiation, skin tissues were collected for histology, and thymus tissues were collected for gene and protein testing. Results: Animal model of skin damage was successfully established. The expression of macrophage (F4/80) increased after irradiation, and F4/80 produced cytokines. Through the flow which was activated by inflammatory factors in the blood, DNA damage and the expression of inflammatory-related cytokines in non-irradiated area of the thymus peaked at 15 d after irradiation. Moreover, HMGB1 treatment increased the expression at 1 d after intraperitoneal injection, and GA solution decreased the expression of inflammatory-related cytokines. Conclusion: When radiation damages the skin, it can cause damage to other organs through the circulation, and an anti-inflammatory GA solution reduced inflammatory responses, which are required to modify radiation-induced systemic effects with anti-inflammatory drugs or agents that affect pathways that cause bystander instability.
کلیدواژه‌های انگلیسی مقاله Radiation induced bystander effects, thymus, γH2AX, NLRP3, HMGB1.
نویسندگان مقاله | Y.T. Chen
Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China


| C.C. Li
Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China


| Y. Liu
Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China


| Y.Q. Zheng
Centre of Radiation Oncology, Shanxi Cancer Hospital, Taiyuan, Shanxi, China


| X.H. Yang
Shanxi Provincial Cancer Institute Laboratory Animal Center, Shanxi Cancer Hospital, Taiyuan, Shanxi, China


| C.X. Yang
Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China


| M.W. An
Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-2188-11&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Medical Physics
نوع مقاله منتشر شده تحقیق بدیع
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