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Iranian Journal of Parasitology، جلد ۱۶، شماره ۴، صفحات ۵۲۷-۵۳۷
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عنوان انگلیسی Chronic Toxoplasma gondii Infection Potentiates Parkinson’s Disease Course in Mice Model
چکیده انگلیسی مقاله Background: Toxoplasma gondii is a neuroinvasive protozoa pathogen that could manipulate its intermediate host's behavior. However, the possible link between T. gondii infection and the development of neurodegenerative disorders such as Parkinson’s disease (PD) has been proposed, we tested the hypothesis that in chronic toxoplasmosis neuroinflammation, and molecular mediators potentiate behavioral-cognitive impairments in BALB/c mice with PD. Methods: To establish chronic toxoplasmosis by Tehran strain, cysts of T. gondii were injected intraperitoneally into BALB/c mice in Kerman, Iran in 2019. To induce the PD model, mice (BALB/c) were treated with Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The behavioral experiments such as anxiety and motor coordination were performed using the Open field and Rotarod tests. Additionally, we investigated the contribution of Toxoplasma-induced neuroinflammation, and behavioral-cognitive impairments in the PD mice model. Results: Chronic toxoplasmosis caused PD-like symptoms and induced various behavioral changes in infected BALB/c mice. In T. gondii infected+MPTP treated group, T. gondii infection could potentiate PD in infected mice receiving MPTP and caused remarkable dysfunction in motor coordination and change in anxiety and depression-like behaviors similar or more severe than PD group. Conclusion: Chronic T. gondii infection exacerbates pathological progression of PD in BALB/c mice brain by promoting neuroinflammation, and behavioral changes establishing.
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نویسندگان مقاله | Nima Firouzeh
1. Department of Medical Parasitology and Mycology, Afzalipour Medical School, Kerman University of Medical Sciences, Kerman, Iran 2. Vector-Borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Naser Ziaali
1. Department of Medical Parasitology and Mycology, Afzalipour Medical School, Kerman University of Medical Sciences, Kerman, Iran 2. Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran


| Vahid Sheibani
Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran


| Amir Hossein Doustimotlagh
Department of Clinical Biochemistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran


| Ali Afgar
Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran


| Hossein Keshavarz
Department of Medical Parasitology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Saeideh Shojaee
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Teh-ran, Iran


| Reza Shafiei
Vector-Borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Khadijeh Esmaeilpour
Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran


| Zahra Babaei
Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
نشانی اینترنتی https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3323
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