این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Parasitology، جلد ۱۶، شماره ۳، صفحات ۴۴۳-۴۵۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Designing of RNA Molecule Translating for Activitable Melit-tin as Selective Targeting of Leishmania Infected Cells
چکیده انگلیسی مقاله Background: Leishmaniasis is characterized by strong inflammatory responses with high levels of inflammatory cytokines that induce microRNA 21 and matrix metalloproteinases. Melittin has inhibitory effects on proliferation of various cells via induction of apoptosis. Melittin can be integrated in cell membranes and induce apoptosis. Thus, designation of biomolecules for the selective destroy of the infected cells is a treatment option. One approach is the precise engineering of constructs for the selective expression of melittin in the infected cells. Methods: For this aim we designed a construct composing melittin nucleotide sequence and nucleotide sequence coding for polyanionic peptide function inhibitory element to further guarantee the selective function of melittin in inflamed tissues and infected cells, were included in a construct as melittin inhibitor via matrix metalloproteinase degradable linker. Results: Reverse complementary sequences were designed so melittin sequences for the selective targeting of Leishmania could be expressed in infected cells using cell microRNA machinery. Conclusion: Translation machinery in infected cells with increased miR-21 could translate melittin, MMP linker and polyanionic inhibitor through a non-canonical pathway. Then, the MMP linker is degraded and selective killing of Leishmania infected cells would happen.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Soheila Akhzari
Department of Parasitology, School of Veterinary Medicine, University of Tehran, Tehran, Iran


| Sedigheh Nabian
Department of Parasitology, School of Veterinary Medicine, University of Tehran, Tehran, Iran


| Parviz Shayan
Department of Parasitology, School of Veterinary Medicine, University of Tehran, Tehran, Iran


| Ramin Mazaheri Nezhad Fard
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Minoo Soltani
Department of Microbiology and Immunology, School of Veterinary Medicine, University of Tehran, Tehran, Iran


| Mohammad Taheri
2. Rastegar Reference Laboratory, School of Veterinary Medicine, University of Tehran, Tehran, Iran
نشانی اینترنتی https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3225
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات