این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Parasitology، جلد ۱۶، شماره ۱، صفحات ۳۲-۴۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Therapeutic Effect of Chitosan Nanoparticles and Metronidazole in Treatment of Experimentally Giardiasis Infected Hamsters
چکیده انگلیسی مقاله Background: The present study aimed to assess the therapeutic effect of chitosan nanoparticles and metronidazole against Giardia lamblia as well as evaluate the efficacy of loading metronidazole on chitosan nanoparticles. Methods: This study was carried out at medical Parasitology Department, Faculty of Medicine, Zagazig University and Theodor Bilharz Research institute (TBRI) from February 2019 to February 2020 on 45 hamsters. They were divided into 5 groups 9 hamsters each: Group A non-infected hamsters, Group B infected control group, Group C, D and E infected with G. lamblia and treated with Chitosan nanoparticles (CsNPs), metronidazole (MTZ) and metronidazole-loaded chitosan nanoparticles (MTZ-CsNPs) respectively. Results: The highest percentage of reduction in the Giardia cyst and trophozoite counts were in group that received MTZ-CsNPs (94.69%, 94.29%). Lower percentages of reduction were recorded for MTZ treated group (90.15%, 89.52%) and CsNPs treated group (63.64%, 75.24%). Histopathological examination showed marked healing of intestinal mucosa after treatment with MTZ-CsNPs. Conclusion: CsNPs showed a therapeutic effect against Giardia infection in hamsters. Loading of metronidazole on chitosan nanoparticles enhanced therapeutic effect of both CsNPs as well as metronidazole.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Alaaeldin El-GENDY
1. Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt


| Mohammed MOHAMMED
2. Department of Medical Parasitology, Faculty of Medicine, Kafr-Elshiekh University, Kafr-Elshiekh, Egypt


| Marwa GHALLAB
2. Department of Medical Parasitology, Faculty of Medicine, Kafr-Elshiekh University, Kafr-Elshiekh, Egypt


| Marwa ABDEL AZIZ
1. Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt


| Shereen IBRAHIM
1. Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
نشانی اینترنتی https://ijpa.tums.ac.ir/index.php/ijpa/article/view/2771
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات