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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۴، شماره ۴، صفحات ۲۶۵-۲۷۳
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عنوان انگلیسی How to Assess Founder Effect in Patients with Congenital Factor XIII Deficiency
چکیده انگلیسی مقاله Abstract Congenital factor XIII (FXIII) deficiency is an extremely rare bleeding disorder (RBD) with estimated prevalence of one per 2 million in the general population. The disorder causes different clinical manifestations such as intracranial hemorrhage (ICH), recurrent miscarriage, umbilical cord bleeding, etc. High incidence of the disorder might be due to founder effect. To assess founder effect, haplotype analysis is an important step. For this purpose, suitable and reliable genetic markers such as microsatellites (Hum FXIII01 and HumFXIIIA02) and single nucleotide polymorphisms (SNP) are suggested. In the present study we tried to describe evaluation of founder effect in patients with congenital FXIII deficiency via haplotype analysis using suitable genetic markers.
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نویسندگان مقاله | Hojat Shahraki
Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran


| Akbar Dorgalaleh
Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran


| Majid Fathi
Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical Sciences. Tehran- Iran


| Shadi Tabibian
Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran


| Shahram Teimourian
Department of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Hasan Mollanoori
Department of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Alireza Khiabani
School of Medicine, Bam University of Medical Sciences, Bam, Iran


| Farhad Zaker
Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1206
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