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Medical Journal of Islamic Republic of Iran، جلد ۲۹، شماره ۱، صفحات ۳۴۵-۳۵۲
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عنوان انگلیسی Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
چکیده انگلیسی مقاله Background: Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners. Methods : Eighteen male middle-distance runners in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, Coenzyme Q10: 5mg/kg/day) and placebo group (n=9, Dextrose: 5mg/kg/day). After acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). Blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. Lactate, serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and creatine kinase (CK) were analyzed. Repeated ANOVA and Bonferunias a post hoc tests were used to determine the changes in four stages. Differences between groups were determined by t-test. Results : The results showed that acute and short-term Coenzyme Q10 supplementation had not significant effect on basal parameters. The acute coenzyme Q10 supplementation attenuated only the exercise-induced increase in response of the plasma CRP. The short-term (14-day) coenzyme Q10 supplementation attenuated the exercise-induced increase in response of the lactate, serum interleukin-6, tumor necrosis factor-alpha, and CRP in male middle-distance runners. However, the acute and short-term coenzyme Q10 supplementation had not any significant effect on the exercise-induced increase response of total serum creatine kinase. Conclusion : Based on the present results, it can be concluded that the 14-day coenzyme Q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, inflammatory and biochemical parameters. Therefore, short-term coenzyme Q10 supplementation is recommended to reduce exercise-induced adverse consequences.
کلیدواژه‌های انگلیسی مقاله Runners, Coenzyme Q10, Inflammatory, Lactate, Muscle damage.
نویسندگان مقاله مصطفی آرمان فر | mostafa armanfar
exercise physiology department, university of tabriz, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

افشار جعفری | afshar jafari
department of physical education, university of tabriz, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

غلامرضا دهقان | gholam reza dehghan
department of biochemistry, university of tabriz, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

لیلا عبدی زاده | leila abdizadeh
department of sport physiology, faculty of physical education and sport sciences, islamic azad university, karaj, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-833&slc_lang=en&sid=en
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