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Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۵، صفحات ۶۸۲-۶۸۹
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عنوان انگلیسی In vivo murine breast cancer targeting by magnetic iron nanoparticles involving L. GG cytoplasmic fraction
چکیده انگلیسی مقاله Objective(s): Use of chemical anti-cancer drugs frequently creates serious side effects. However, probiotics are natural and treat different kinds of cancer without undesired effects.Materials and Methods: In this study, a nano delivery system was planned to transport the Lactobacillus rhamnosus GG (L. GG) cytoplasmic fraction (Cf) to cancerous tissue in a mouse model. Magnetic iron nanoparticles (MINPs) were synthesized and loaded with L. GG-Cf(0, 0.312, 0.625, 1.25, and 2.5 mg/ml) and were administrated for three weeks to treat experimentally induced murine breast cancer in a constant magnetic field. At the end of the trial, the treating efficacy of this complex molecule was evaluated via western blotting, immunohistochemistry, and qPCR.Results: Results showed that MINPS can deliver and accumulate L. GG-Cf in cancer tissue, and reduce the size and volume of the tumors. Additionally, in cancer tissues of treated mice with 2.5 mg/ml of Cf-MINPs, significantly induced apoptosis was seen compared with untreated mice (control), and our data proved that this induction may be due to the caspase-3 pathway.Conclusion: L. GG-Cf could treat murine breast cancer, and MINPs are a suitable candidate for drug delivery because of their safety, uniformity, and magnetic properties.
کلیدواژه‌های انگلیسی مقاله Anti-cancer, Drug Delivery, In vivo, Nanoparticles, Probiotic, 4T1
نویسندگان مقاله | Salar Mokriani
Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran


| Amir Tukmechi
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azarbaijan Province, Iran


| Naser Harzandi
Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran


| Leila Jabalameli
Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_17948.html
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