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Research in Pharmaceutical Sciences، جلد ۱۶، شماره ۶، صفحات ۵۵۹-۵۷۴
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عنوان انگلیسی Anti-angiogenic peptides application in cancer therapy; a review
چکیده انگلیسی مقاله Cancer is a disease advanced via surplus angiogenesis. The development of new anti-angiogenic therapeutic agents with more efficacy and fewer side effects is still quite necessary. Conventional therapies saving the life of many cancer patients but due to drug resistance and lack of specificity utilizing these methods is faced with limits. Recently, new therapeutic agents have been developed and used to treat cancers such as scaffold proteins, monoclonal antibodies, tyrosine kinase inhibitors, and peptides. In antiangiogenic drug development, anti-angiogenic peptides design is a significant aim. Peptides have developed as substantial therapeutics that are being carefully investigated in angiogenesis-dependent diseases because of their high penetrating rate into the cancer cells, high specificity, and low toxicity. In this review, we focus on anti-angiogenic peptides in the field of cancer therapy that are designed, screened, or derived from nanobodies, mimotopes, phage displays, and natural resources.
کلیدواژه‌های انگلیسی مقاله Keywords, Angiogenesis,Cancer,Nanobodies,Natural resource,Peptide,Phage display.
نویسندگان مقاله | Alireza Shoari
2Department of Genetics and Advanced Medical Technology, Medical Biotechnology Research Center, Faculty of Medicine, AJA University of Medical Sciences, Tehran, I.R. Iran.


| Farnaz Khodabakhsh
3Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, I.R. Iran.


| Reza Ahangari Cohan
4Department of Medical Laboratory, Kashan University of Medical Sciences, Kashan, I.R. Iran.


| Morteza Salimian
5Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, I.R. Iran.


| Elmira Karami


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2090
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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