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Research in Pharmaceutical Sciences، جلد ۱۶، شماره ۵، صفحات ۴۶۴-۴۷۳
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چکیده فارسی مقاله
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عنوان انگلیسی Anti-inflammatory effect of Perilla frutescens seed oil rich in omega-3 fatty acid on dextran sodium sulfate-induced colitis in mice
چکیده انگلیسی مقاله Background and purpose: Ulcerative colitis is a chronic inflammatory bowel disease that involves diffused inflammation of the large intestine. Omega-3 fatty acid (FA) has been known to regulate the inflammatory response associated with ulcerative colitis pathogenesis. Perilla frutescens is a valuable source of omega-3 FA and α-linolenic acid (ALA) contained in its seed oil. Therefore, the aim of this study was to evaluate the anti-inflammatory effect of Perilla seed oil (PSO) on colitis induced by dextran sulfate sodium (DSS) in a mouse model. Experimental approach: PSO was extracted using a cold-pressed extractor and FA composition of PSO was analyzed by GC-MS. Acute colitis in mice was induced with 3% DSS in drinking water for 7 days. Some mice were treated with PSO (20, 100, 200 mg/kg BW) for 3 weeks before the DSS administration. Sulfasalazine was used as a positive control. The clinical features, histopathologic, serum, and gene expression of proinflammatory cytokines in the colon were assessed. Finding/Results: PSO contained the highest proportion of ALA (61.51%). Furthermore, PSO pretreatment evidently reduced body weight loss, diminished diarrhea, gross bleeding, and DSS-induced colon shortening. PSO pretreatment attenuated histopathological changes in response to DSS-induced colitis. PSO pretreatment also markedly decreased inflammatory response in serum and the colon tissue of DSS-induced mice. Conclusion and implication: ALA in PSO is suggested to be mainly responsible for the reduction of DSS-induced colitis through suppressing inflammatory markers. PSO could be further developed as a functional health supplement, which would be beneficial for anti-inflammation in the colonic mucosa.
کلیدواژه‌های انگلیسی مقاله Anti-inflammation,Inflammatory bowel disease,Inflammatory cytokines,Omega-3 fatty acid,Perilla seed oil.
نویسندگان مقاله | Napapan Kangwan
2Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, Thailand.


| Komsak Pintha
3School of Traditional and Alternative Medicine, Chiang Rai Rajabhat University, Chiang Rai, Thailand.


| Chakkrit Khanaree
4Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.


| Sarawut Kongkarnka
5Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.


| Teera Chewonarin
2Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, Thailand.


| Maitree Suttajit


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2082
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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