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Medical Laboratory Journal، جلد ۱۵، شماره ۲، صفحات ۲۳-۲۷
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عنوان انگلیسی Docetaxel Toxicity Optimization in Esophageal Squamous Cell Carcinoma Cell Line YM-1: A Study of Cell Cycle and Doubling Time Effect
چکیده انگلیسی مقاله Background and objectives: Docetaxel is a chemotherapeutic agent commonly used for treatment of many cancers, including esophageal squamous cell carcinoma. Docetaxel induces G2/M phase cell cycle arrest and ultimately cell death. In this study, we aimed to assess the effects of docetaxel on YM1 cells considering exposure time and dose. Methods: After calculating the doubling time of YM1 cells, the anti-proliferative effect of different concentrations of docetaxel () [A1]  after 24, 48 and 72 hours was assessed by the standard colorimetric assay. In addition, the effect of docetaxel on cell cycle was evaluated by flow cytometry. Results: The results showed that docetaxel toxicity was not significant until 24 hours at the tested concentrations (P>0.05). In addition, the effect of docetaxel on the cells was time-dependent at all tested concentrations. Overall, the duration of exposure to docetaxel had more significant role in docetaxel toxicity in YM1 cells compared to concentration. Conclusion: Our findings suggest that the cytotoxicity of docetaxel on YM1 cells is time-dependent.  [A1]Please write the concentrations
کلیدواژه‌های انگلیسی مقاله Docetaxel,Cell cycle,Esophageal Neoplasms
نویسندگان مقاله | Boshra haghi
Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Marie Saghaeian jazi
Stem cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Mahdi zarie
Department of Molecular Medicine, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran


| Ayyoob Khosravi
Department of Molecular Medicine, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran


| mahboubeh tajaldini
Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Jahanbakhsh Asadi
Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-868-2&slc_lang=en&sid=1
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