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International Journal of Molecular and Cellular Medicine، جلد ۹، شماره ۴، صفحات ۲۴۶-۲۵۴
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عنوان انگلیسی Aberrant Expression of Immune-related MicroRNAs in Pediatric Patients with Asthma
چکیده انگلیسی مقاله MicroRNAs (miRNAs) have been implicated as regulatory molecules that could play a considerable role in the pathogenesis of different diseases including asthma. This work aims at exploring the role of miR-146a and miR-106b in the pathogenesis of asthma and their association with asthma severity, IgE, and inflammatory cytokines in asthmatic children. Thirty asthmatic children and twenty age-matched healthy children aged 4-17 years old were enrolled. Expression of plasma miR-146a and miR-106b was measured using quantitative real-time PCR. Plasma levels of interleukin-5 (IL-5) and interleukin-13 (IL-13) were assessed using ELISA. Lung functions were measured by Spirometry. MiR-146a and miR-106b were significantly over-expressed in asthmatic children compared to healthy children. A significant positive correlation between total IgE and both miR-146a and miR-106b was found while no significant correlation could be detected between these miRNAs and asthma severity in asthmatic children. Plasma levels of IL-5 and IL-13 were non-significantly higher in asthmatic children compared to healthy children, and there was no significant correlation between them and both miR-146a and miR-106b expressions in the asthmatic children.  The aberrant expression of immune-related miRNAs (miR-146a and miR-106b) and inflammatory cytokines (IL-5 and IL-13) among asthmatic children suggest their probable role in asthma pathogenesis.
کلیدواژه‌های انگلیسی مقاله Asthma, microRNAs, cytokines, children, IL-5, IL-13
نویسندگان مقاله | Hala Gouda Elnady
Department of Child Health, Medical Research Division, National Research Center, Egypt.


| Lobna Sayed Sherif
Department of Child Health, Medical Research Division, National Research Center, Egypt.


| Naglaa Mohamed Kholoussi
Immunogenetics Department, Human Genetics and Genome Research Division, National Resrearch Center, Egypt.


| Mona Ali Azzam
Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt; McMaster University, Hamilton, Canada.


| Ahmed Rashad Foda
Department of Child Health, Medical Research Division, National Research Center, Egypt.


| Iman Helwa
Immunogenetics Department, Human Genetics and Genome Research Division, National Resrearch Center, Egypt.


| Rania Nabil Sabry
Department of Child Health, Medical Research Division, National Research Center, Egypt.


| Eman Eissa
Immunogenetics Department, Human Genetics and Genome Research Division, National Resrearch Center, Egypt.


| Reham Faisal Fahmy
Department of Child Health, Medical Research Division, National Research Center, Egypt.
نشانی اینترنتی http://ijmcmed.org/browse.php?a_code=A-10-2996-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular & Cellular Immunology
نوع مقاله منتشر شده Original Article
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