این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Molecular and Cellular Medicine، جلد ۹، شماره ۴، صفحات ۳۰۷-۳۱۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی PD-1, TIM-3, and LAG-3 Expression in T Cells in a Patient with Recurrent Ossifying Fibroma: A Case Report
چکیده انگلیسی مقاله Central ossifying fibroma is a benign, slow-growing tumor of mesenchymal origin with a predilection for the mandibular premolar and molar areas. The immunophenotype of T cells involved in the antitumor response against this benign tumor is unknown. In this case report, we described a case of a 48-year-old woman presenting with a very large recurrent ossifying fibroma in the mandible, which was successfully treated with hemimaxillectomy. In addition, we evaluated the expression of programmed cell death 1 receptor (PD-1), lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), CD69 (activation inducer molecule) and CD25 (α chain of the high-affinity IL-2 receptor) in T cell populations from the tumor and peripheral blood of this uncommon lesion. The patient presented recurrent ossifying fibroma, and the tumor-infiltrating and peripheral blood T cells showed expression of PD-1, LAG-3, and TIM-3, suggesting an exhausted T cell response.
کلیدواژه‌های انگلیسی مقاله Immune checkpoint proteins, ossifying fibroma, programmed cell death 1 receptor, T-lymphocytes
نویسندگان مقاله | Alejandro García-Muñoz
Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.


| Nayeli Goreti Nieto-Velázquez
Research División, Hospital Juárez de México, Mexico City, Mexico.


| Gabriela Damian-Morales
Research División, Hospital Juárez de México, Mexico City, Mexico.


| Carlos Liceaga-Escalera
Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.


| Luis Alberto Montoya-Perez
Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.


| Madeleine Cruz-Vélez
Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.


| Pabel Antonio Gómez-Hernández
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México.


| Cynthia Trejo-Iriarte
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México.


| Rodolfo Pastelin-Palacios
Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México.


| Mario Moreno-Eutimio
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México.
نشانی اینترنتی http://ijmcmed.org/browse.php?a_code=A-10-2913-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer
نوع مقاله منتشر شده Case Report
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات