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International Journal of Pediatrics، جلد ۹، شماره ۱۰، صفحات ۱۴۶۵۶-۱۴۶۶۲
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عنوان انگلیسی Efficacy of Saccharomyces Boulardii in Pediatrics with Functional Abdominal Pain: A Randomized Controlled Trial
چکیده انگلیسی مقاله Background: Considerable increase in gut motility after probiotic supplementations consumption is indicated in recent studies. The present study conducted to clarify whether supplementation with Saccharomyces boulardii can palliate the abdominal pain frequency in children with Functional Abdominal Pain (FAP).Methods: The present clinical trial was conducted on children referred to the Pediatric Departments of the Emam Khomeini hospital, Ilam, Iran, and Shahid Beheshti Hospital, Kashan, Iran. Finally, patients were randomized to receive either 250 mg oral supplementation with Saccharomyces boulardii supplementation, Zist Thakhmir company, or placebo, twice daily for 3 weeks before the first clinical assessment. The intensity of the symptoms were evaluated using the OUCHER PAIN scale.Findings: A total of 104 FAP children with a mean age of 9.51±3.52 years enrolled in the study. 52 of them randomly were assigned to the treatment group and 52 patients were assigned to the placebo group. Statistical analysis demonstrated that treatment with Saccharomyces boulardii was effective in the treatment group after the 1st week of study. (P-value=0.001)Conclusion: To best of our knowledge, our investigation is the first trial which assess a correlation between taking Saccharomyces boulardii and symptoms reduction in FAP children through its probiotic effects. This disorder can be considered as a multifactorial disease which further investigations is needed to figure its risk factors and treatment modalities.
کلیدواژه‌های انگلیسی مقاله Functional Abdominal Pain, Saccharomyces boulardii, Randomized controlled trial, Pediatrics
نویسندگان مقاله | Gholamreza kalvandi
Associate Professor of Pediatrics Gastroenterology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran


| Ali Dehdashtizadeh
Department of pediatrics, Ilam University of medical sciences, Ilam, Iran.


| Abbas Taghavi Ardakani
Associate professor, Department of Pediatric, Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran


| koroush sayehmiri
Department of Biostatistics, School of Health, Ilam University of Medical Sciences, Ilam, Iran


| Naser Abbasi
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
نشانی اینترنتی https://ijp.mums.ac.ir/article_18053.html
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