این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Pediatrics، جلد ۹، شماره ۷، صفحات ۱۳۹۳۷-۱۳۹۴۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Accuracy of Enzyme-Linked Immunosorbent Assay in the Diagnosis of COVID-19 in Iranian Children
چکیده انگلیسی مقاله Background The present study aimed to evaluate the accuracy of enzyme-linked immunosorbent assay (ELISA) compared to the real-time reverse transcription-polymerase chain reaction (rRT-PCR) in the diagnosis of coronavirus disease 2019 (COVID-19) in Iranian children. Materials and Methods In this cross-sectional study, 90 children under 15 years of age were randomly selected from suspects of COVID-19 referred to the Tabriz Children Hospital, the main pediatric COVID-19 diagnostic center of Tabriz, from May 21, 2020 to June 21, 2020. Blood and nasopharyngeal samples were taken simultaneously at the referring time. The diagnostic accuracy of ELISA-based IgM and IgG antibody tests for COVID-19 were compared with the rRT-PCR. Results The calculated sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, overall diagnostic accuracy, and diagnostic odds ratio were 0.5745, 0.9767, 0.9643, 0.6774, 24.66, 0.4357, 0.7667, and 56.60 for IgM; and 0.6170, 0.9302, 0.9355, 0.6897, 8.84, 0.4117, 0.7667, and 21.47 for IgG, respectively. Conclusion Due to the lower sensitivity of antibody detection-based serological tests compared to rRT-PCR, they cannot be considered as initial and reliable tests for the diagnosis of COVID-19. It can be suggested that the serological tests be only used as complementary tests to rRT-PCR or for monitoring the immune response of children with COVID-19.
کلیدواژه‌های انگلیسی مقاله Children, COVID-19, Diagnosis, Real-time RT-PCR, SARS-CoV-2
نویسندگان مقاله | Vahid Tarmahi
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Mohammadreza Afghan
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Sina Raeisi
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Hamid Reza Yousefi Nodeh
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Mona Tamaddon
Stem Cell Technology Research Center, Tehran, Iran


| Fatemeh Moahamadzadeh
Department of Laboratory Sciences, Marand Branch, Islamic Azad University, Marand, Iran


| Nader Mohammadzadeh
Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Zakiyeh Ebadi
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی https://ijp.mums.ac.ir/article_17309.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات