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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۶، شماره ۲، صفحات ۱۱۸-۱۲۵
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عنوان انگلیسی Review SARS-CoV-2 Infection: A Possible Risk Factor for Incidence and Recurrence of Cancers
چکیده انگلیسی مقاله COVID-19 and malignancy can affect the susceptibility of one another. The lymphopenia-related immunosuppression, functional exhaustion of cytotoxic lymphocytes (such as T-cells and natural killer cells), hyperinflammatory responses, and perhaps reactivation of the latent oncogenic viruses may directly and/or indirectly play a role in the cancer development and recurrence in severe COVID-19 patients perhaps by breaking the altogether mechanisms of the immune-surveillance. SARS-CoV-2-infected malignant patients may be at higher risk of death of their cancer than SARS-CoV-2-uninfected patients with the same cancers. On the other side, patients with underlying cancer are highly vulnerable to SARS-CoV-2 infection compared with non-cancerous individuals, due to their immunocompromised state resulting from malignancy, chemotherapy, and other concomitant abnormalities. SARS-CoV-2-infected cancerous patients are unable to produce an effective anti-virus immune response and may exhibit more severe forms of COVID-19. This review described the possible impacts of SARS-CoV-2 infection on the development of cancer and cancer recurrence, and the potential cancer impacts on COVID-19 development, while the possible interventions are highlighted. 
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نویسندگان مقاله | Abdollah Jafarzadeh
1) Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran 2)Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Rohit Gosain
Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Street, Buffalo, NY, 14263, USA


| Seyed Mohammad Javad Mortazavi
Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Maryam Nemati
1)Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 2)Department of Hematology and Laboratory Sciences, School of Para-Medicine, Kerman University of Medical Sciences, Kerman, Iran


| Sara Jafarzadeh
Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran


| Abbas Ghaderi
Shiraz University of Medical Sciences, School of Medicine, Shiraz Institute for Cancer Research, Shiraz, Iran
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1408
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