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Medical Journal of Islamic Republic of Iran، جلد ۲۹، شماره ۱، صفحات ۳۲۵-۳۳۲
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عنوان انگلیسی Anti-hemorrhagic activity of Punicagranatum L. flower (Persian Golnar) against heavy menstrual bleeding of endometrial origin: a double-blind, randomized controlled trial
چکیده انگلیسی مقاله Background: Heavy menstrual bleeding of endometrial origin (HMB) is a major healthcare problem in premenopausal women and affects several aspects of women’s health and quality of life (QoL). The aim of this study was to compare the efficacy of Persian Golnar (PG) and tranexamic acid (TA) on heavy menstrual bleeding of endometrial origin (HMB) and patients’ QoL. Methods : A double-blind randomized controlled trial with parallel design and block randomization technique was conducted. A total of 94 women with HMB were randomly assigned to take either PG or TA for 5 days from day 1 of menses for three consecutive menstrual cycles. Blood loss was measured by the pictorial blood loss assessment chart (PBAC). Hematological assessments were made before the intervention and after treatment. QoL as a secondary outcome was evaluated using SF-36 and the menorrhagia questionnaire (MQ). Statistical analysis was performed using t-test, paired t-test, χ2 test, Mann–Whitney test, and Wilcoxon signed-rank test. Results : In each group, 38 women (80.8%) completed the 3-month follow-up. Both PG and TA reduced blood loss. PBAC mean (SD) score was reduced from 304.92 (176.17) and 304.44 (192.72) to 164.60 (100.24) and 143.13 (96.07) after the third treatment cycle, respectively (p< 0.001). Furthermore, mean hemoglobin, Hb (SD) concentrations in the PG and TA groups increased significantly from 12.06(0.86) and 11.53(0.86)mg/dl to 13.02 (0.82) and 12.72 (0.88)mg/dl (p< 0.001). QoL was significantly improved in both groups (p< 0.001). However, there were no significant differences between the groups after the intervention. Conclusion : The results of the present study demonstrate the efficacy of PG in treating HMB in terms of clinical and QoL indicators.
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نویسندگان مقاله آزیتا گشتاسبی | azita goshtasebi
family health research group, health metrics research center, iranian institute for health sciences research, acecr, tehran, iran.


زیبا مزاری | ziba mazari
family health research group, health metrics research center, iranian institute for health sciences research, acecr, tehran, iran.


سمیرا بهبودی گندوانی | samira behboudi gandevani
reproductive endocrinology research centre, research institute for endocrine science, shaheedbeheshti university of medical science, tehran, iran.


محسن ناصری | mohsen naseri
shahed traditional iranian medicine research center, tehran, iran.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-836&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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