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Middle East Journal of Digestive Diseases، جلد ۱، شماره ۱، صفحات ۱۱۸-۱۲۳
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عنوان انگلیسی Association of Interleukin-28B Polymorphisms (rs12979860 C/T, rs12980275 A/G, rs8099917 T/G) and Risk of Hepatocellular Carcinoma in an Iranian Population
چکیده انگلیسی مقاله BACKGROUND : Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. The association of interleukin 28B (IL-28B) polymorphisms and HCC has been investigated in several populations. However, the findings are controversial. This study aimed to address the association between IL-28B polymorphisms (rs 8099917 T/G, rs12979860 C/T, rs12980275 A/G) and the risk of HCC in an Iranian population. METHODS : We have evaluated the association between IL-28B polymorphisms (rs 8099917 T/G, rs12979860 C/T, rs12980275 A/G) and HCC in 180 Iranian individuals (60 patients with HCC and 120 healthy matched controls) using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method. Single nucleotide polymorphism (SNP) association analysis and also haplotypes were estimated using the SNPstats online software. RESULTS: There was no significant association between these three polymorphisms of IL-28B and HCC (P>0.05). Moreover, haplotype analysis showed no significant association between the haplotypes and HCC. CONCLUSION : There was no association between IL-28B polymorphisms and HCC in an Iranian population.
کلیدواژه‌های انگلیسی مقاله Hepatocellular carcinoma,Interleukin 28B,Polymorphism
نویسندگان مقاله | Leila Hajizadeh
Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Nader Mansour Samaei
Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Afsaneh - Bazgir
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Mehdi Agha Gholizadeh
Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Ayoob Khosravi


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2357
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