این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۲۹، شماره ۱، صفحات ۲۹۲-۳۰۲
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عنوان انگلیسی Comparison of quadruple and triple Furazolidone containing
چکیده انگلیسی مقاله Background: The effectiveness of classic standard triple therapy regimen of helicobacter pylori (H. pylori) eradication has decreased to unacceptably low levels, largely related to development of resistance to metronidazole and clarithromycin. Thus successful eradication of H. pylori infections remains challenging. Therefore alternative treatments with superior effectiveness and safety should be designed and appropriately tested in all areas depending on the native resistance patterns. Furazolidone has been used successfully in eradication regimens previously and regimens containing furazolidone may be an ideal regimen. Methods : H. pylori infected patients with proven gastric or duodenal ulcers and /or gastric or duodenal erosions at Imam Khomeini Hospital in Sari/Northern Iran, were randomly allocated into three groups: group A (OABF) with furazolidone (F) (200 mg bid.), group B (OABM-F) metronidazole (M) (500 mg bid.) for the first five days, followed by furazolidone (F) (200 mg bid.) for the second five days and group C (OAF) with furazolidone (F) (200 mg tid.). Omeprazole (O) (20 mg bid.) and amoxicillin (A) (1000 mg bid.) were given in all groups bismuth (B) (240 mg bid.) was prescribed in groups A & B. Duration of all eradication regimens were ten days. Eight weeks after treatment, a 14C-urea breath test was performed for evaluation of H. pylori eradication. Results : A total of 372 patients were enrolled in three groups randomly (124 patients in each group) 120 (97%) patients in group A (OABF), 120 (97%) in group B (OABM-F) and 116 (93%) in group C (OAF) completed the study. The intention-to-treat eradication rates were 83.7% (95% CI= 77.3–90.4), 79.8% (95% CI=72.6–87), and 84.6% (95% CI= 78.2–91.1) and per-protocol eradication rates were 86.6% (95% CI= 80.5–92.8), 82.5% (95% CI= 75.6–89.4), and 90.5% (95% CI= 85.1–95.9) for groups OABF, OABM-F, and OAF, respectively. No statistical significant differences were found in case of severe drug adverse effects between the above mentioned three groups (p>0.05). The most common side effects, namely nausea and fever, occurred in all groups, but more frequently in group C (OAF) (p< 0.05). Conclusion : In developing countries such as Iran, furazolidone-based regimens can substitute clarithromycin-based regimens for H. pylori eradication because of a very low level of resistance, low cost and high effectiveness. Considering per-protocol eradication rate of ten days OAF regimen, and the acceptable limit of ninety percent, we recommend this regimen in developing countries such as Iran to be substituted of classic standard triple therapy. In order to minimize rare serious adverse effects, one week high dose OAF regimen should be taken into consideration in other studies.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مرجان مخترع | marjan mokhtare
colorectal research center, iran university of medical sciences, rasool-e-akram hospital, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

وحید حسینی | vahid hosseini
gut and liver research center, mazandaran university of medical sciences, imam khomeini hospital, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

حافظ تیرگرفاخری | hafez tirgar fakheri
gut and liver research center, mazandaran university of medical sciences, imam khomeini hospital, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

ایرج ملکی | iradj maleki
gut and liver research center, mazandaran university of medical sciences, imam khomeini hospital, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

ترنگ تقوایی | tarang taghvaei
gut and liver research center, mazandaran university of medical sciences, imam khomeini hospital, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

سید محمد ولی زاده | seyed mohammad valizadeh
gut and liver research center, mazandaran university of medical sciences, imam khomeini hospital, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

حسین سرداریان | hossein sardarian
guilan university of medical sciences, international branch, bandar anzali,guilan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

شهرام آگاه | shahram agah
colorectal research center, iran university of medical sciences, rasool-e-akram hospital, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

علیرضا خلیلیان | alireza khalilian
department of biostatistics and community medicine, imam khomeini hospital, sari, iran.

سازمان های دیگر: بیمارستان امام خمینی

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-812&slc_lang=en&sid=en
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